This is a non-interventional prospective observational study in patients receiving Vedolizumab therapy for IBD. Sites will enroll patients with moderately to severely active IBD (UC or CD), initiating or ongoing IV induction treatment with vedolizu...

Clinical Studies - Jul 14, 2022 - Dec 31, 2023

Automatically Closed

Project leader: Brand Stephan
Members: Eckhold Annika, König Marius, Krieger-Grübel Claudia

A Phase 3, Multicenter, Open-Label, Long-Term Extension Study to Evaluate the Long-Term Efficacy and Safety of Mirikizumab in Patients with Crohn's Disease

Clinical Studies - Jun 7, 2022 - Dec 31, 2024

Ongoing

Project leader: Brand Stephan
Members: Eckhold Annika, Krieger-Grübel Claudia, König Marius

The Crohn’s disease exclusion diet (CDED) for induction and maintenance of remission in Crohn’s patients with or without additional medical therapy. An open label observational trial

Clinical Studies - Jun 1, 2022 - Dec 30, 2023

Automatically Closed

Project leader: Krieger-Grübel Claudia
Members: Brand Stephan, Eckhold Annika

This is a double-blind, randomised, multicentre, placebo-controlled, comparative phase IIb dose-finding and efficacy trial. The trial will be conducted with four treatment groups in the form of a parallel group comparison and will serve to compare...

Clinical Studies - Jun 1, 2022 - Dec 31, 2024

Ongoing

Project leader: Brand Stephan
Members: Eckhold Annika, König Marius, Krieger-Grübel Claudia, Truniger Samuel

A Phase 2, Multicenter, Dose-finding, Double blinded, Pla-cebo- Controlled Study to Evaluate the Safety and Effi-cacy of Efavaleukin Alfa Induc-tion Therapy in Patients with Mederatly to Severely UC

Clinical Studies - Apr 25, 2022 - Dec 31, 2023

Automatically Closed

Project leader: Brand Stephan
Members: Eckhold Annika, Krieger-Grübel Claudia

This is a national multi-center cohort confirmatory study which is designed as a prospective observational trial combined with retrospective data collection. Prospective data are collected through a patient questionnaire and assessment of blood sam...

Clinical Studies - Jan 20, 2022 - Mar 30, 2023

Automatically Closed

Project leader: Brand Stephan
Members: König Marius, Dütschler Joel, Krieger-Grübel Claudia, Eckhold Annika, Truniger Samuel, Frei Nicola Fabian, Albrich Werner

A Phase 3b, Randomized, Double-Blind, Parallel-Arm, Placebo- and Active- Controlled Treat-Through Study of Mirikizumab and Vedolizumab in participants with Moderately to Severely Active Ulcerative Colitis

Clinical Studies - Feb 1, 2021 - Jan 1, 2024

Completed

Project leader: Brand Stephan
Members: Smolders Jolijn, Krieger-Grübel Claudia

A Phase 3, Multicenter, Open-Label Extension Study to Evaluate the Long-Term Efficacy and Safety of Mirikizumab in Patients with Moderately to Severely Active Ulcerative Colitis LUCENT 3

Clinical Studies - Jan 29, 2021 - Dec 1, 2024

Automatically Closed

Project leader: Brand Stephan
Members: Krieger-Grübel Claudia, Smolders Jolijn

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Induction Study to Evaluate the Efficacy and Safety of Upadacitinib (ABT-494) in Subjects with Moderately to Severely Active Ulcerative Colitis

Clinical Studies - Jan 1, 2019 - Aug 1, 2020

Completed

Project leader: Sulz Michael
Members: Brand Stephan, Krieger-Grübel Claudia, Smolders Jolijn

A Phase 3, Multicenter, Randomized, Double-Blind, Placebo- and Active- Controlled, Treat-Through Study to Evaluate the Efficacy and Safety of Mirikizumab in Patients with Moderately to Severely Active Crohn's Disease

Clinical Studies - Jan 1, 2019 - Dec 1, 2022

Automatically Closed

Project leader: Brand Stephan
Members: Sulz Michael, Smolders Jolijn, Krieger-Grübel Claudia

A Phase 3, Multicenter, Randomized, Double-Blind, Parallel, Placebo-Controlled Induction Study of Mirikizumab in Conventional-Failed and Biologic-Failed Patients with Moderately to Severely Active Ulcerative Colitis LUCENT 1

Clinical Studies - Jan 1, 2018 - Feb 1, 2021

Completed

Project leader: Brand Stephan
Members: Krieger-Grübel Claudia, Sulz Michael, Smolders Jolijn

A Phase 3, Multicenter, Randomized, Double-Blind, Parallel-Arm, Placebo-Controlled Maintenance Study of Mirikizumab in Patients with Moderately to Severely Active Ulcerative Colitis LUCENT 2

Clinical Studies - Jan 1, 2018 - Jun 1, 2021

Automatically Closed

Project leader: Brand Stephan
Members: Sulz Michael, Krieger-Grübel Claudia, Smolders Jolijn

A MULTICENTER, MULTI-NATIONAL, RANDOMISED, DOUBLE-BLIND, PLACEBO CONTROLLED, PARALLEL GROUP, PHASE IIA STUDY TO EVALUATE THE EFFICACY, SAFETY AND TOLERABILITY OF AN ANTHOCYANIN RICH EXTRACT (ACRE) IN PATIENTS WITH ULCERATIVE COLITIS.

Clinical Studies - Jan 1, 2018 - Jul 1, 2021

Completed

Project leader: Brand Stephan
Members: Stillhard Roman, Sulz Michael, Krieger-Grübel Claudia, Smolders Jolijn

A Phase 3, Randomized, Double-Blinded, Placebo-Controlled, Multicenter Study of Amiselimod (MT-1303) in the Induction and Maintenance of Clinical Response and Remission in Subjects With Moderate to Severe Ulcerative Colitis

Clinical Studies - Jun 1, 2017 - Sep 27, 2022

Automatically Closed

Members: Knellwolf Christina, Dora Barbara, Krieger-Grübel Claudia, Sulz Michael

A Phase 3, randomized, double-blind, placebo-controlled, multicenter study to investigate the efficacy and safety of mongersen (GED-0301) for the treatment of subjects with active Crohn’s disease.

Clinical Studies - Dec 1, 2016 - Dec 1, 2018

Completed

Members: Dora Barbara, Knellwolf Christina, Krieger-Grübel Claudia, Sulz Michael

Randomized, double-blind, double-dummy, placebo-controlled, Phase III clinical trial on the efficacy and safety of a 48-weeks treatment with gastroresistant phosphatidylcholine (LT-02) versus placebo versus mesalamine for maintenance of remission in...

Clinical Studies - Dec 1, 2016 - Dec 1, 2018

Completed

Members: Dora Barbara, Knellwolf Christina, Krieger-Grübel Claudia, Sulz Michael

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of ABT-494 for Induction and Maintenance Therapy in Subjects with Moderately to Severely Active Ulcerative Colitis

Clinical Studies - Dec 1, 2016 - Dec 1, 2018

Automatically Closed

Members: Dora Barbara, Knellwolf Christina, Krieger-Grübel Claudia, Sulz Michael

Entyvio (vedolizumab) long-term safety study: An international observational prospective cohort study comparing vedolizumab to other biologic agents in patients with ulcerative colitis or Crohn’s Disease. This is a prospective, observational, multi-...

Clinical Studies - Jul 28, 2016 - Jun 28, 2022

Automatically Closed

Project leader: Brand Stephan
Members: Dora Barbara, Knellwolf Christina, Sulz Michael, Krieger-Grübel Claudia

Randomized, double-blind, double-dummy, placebo-controlled, Phase III clinical trial on the efficacy and safety of a 12-weeks add-on treatment with LT-02 (gastro-resistant phosphatidylcholine granules) vs. placebo in patients with ulcerative colitis...

Clinical Studies - Mar 1, 2016 - Dec 31, 2017

Aborted

Members: Dora Barbara, Knellwolf Christina, Sulz Michael, Krieger-Grübel Claudia

Gastroösophageale Refluxerkrankung (GERD) mit persistierenden Symptomen (d. h. Sodbrennen und Regurgitation) trotz Einnahme einer stabilen Dosis eines Protonenpumpenhemmers (PPI). M0003 wird als mögliche Behandlung für gastroösophagealen Reflux (GE...

Clinical Studies - May 1, 2011 - Sep 30, 2011

Automatically Closed

Project leader: Borovicka Jan
Members: Krieger-Grübel Claudia, Künzler-Heule Patrizia