Unit
Division of Infectious Diseases & Hospital Epidemiology
INFEKT · Dept. I
mBiomR; Unravelling the Mechanisms and Dynamics Underlying the Response of Intestinal Bacteria from the ESKAPE group to Antimicrobial Treatment
Mar 1, 2023With this longitudinal, large-scale metagenomics, multi-assay study (mBiomR) on adult hospitalised Population ,which we will start in the beginning of 2023, we aim to explore the distribution dynamics of Gram-negative pathogens and Enterococcus faec...
Fundamental Research - Mar 1, 2023 - Mar 1, 2027
Scheduled
Project leader: Babouee Flury Baharak
Symptoms compatible with long-COVID in SARS-CoV-2 positive and negative healthcare workers – analysis of prospective cohort data
Mar 1, 2022In this analysis, we are aiming to determine the impact of viral variant and of vaccination on the occurence and the temporal dynamics of long COVID symptoms in healthcare workers.
Healthcare Research - Mar 1, 2022 - Dec 31, 2022
Automatically Closed
Project leader: Kohler Philipp
Analysis of the effect of biological therapy on SARS-CoV-2-specific antibody levels following booster vaccination in patients with inflammatory bowel disease
Jan 20, 2022This is a national multi-center cohort confirmatory study which is designed as a prospective observational trial combined with retrospective data collection. Prospective data are collected through a patient questionnaire and assessment of blood sam...
Clinical Studies - Jan 20, 2022 - Mar 30, 2023
Ongoing
Project leader: Brand Stephan
Members: König Marius, Dütschler Joel, Krieger-Grübel Claudia, Eckhold Annika, Truniger Samuel, Frei Nicola Fabian, Albrich Werner
Regional spread of an untypical ESBL-E.coli ST131H89 clone among different human and environmental reservoirs in Western Switzerland
Jan 1, 2022We are investigating the clonal dissemination of a novel ESBL-producing Escherichia coli (ST131 H89) in Western Switzerland.
Healthcare Research - Jan 1, 2022 - Jun 30, 2023
Ongoing
Project leader: Kohler Philipp
Deciphering the resistance mechanisms of E. coli and P. aeruginosa from UTI and SSI in Tanzania
Nov 1, 2021This study investigates antimicrobial resistance mechanisms of E.coli and P. aeruginosa isolated from patients with urinary tract infections or surgical site infections. The samples are collected from patients at St. Francis Referral Hospital in Ifak...
Fundamental Research - Nov 1, 2021 - Nov 1, 2024
Ongoing
Project leader: Babouee Flury Baharak
Members: Macha Magreth
Cognitive Outcome 1 year after COVID-19 – A Pilot Study (CogCOVID)
Oct 19, 2021This prospective observational pilot study examines cognitive function 1 year after SARS-Cov-2 disease. Study population consists of formerly hospitalized non-ventilated COVID-19 patients (nvCOVID) and ventilated patients with COVID-19-ARDS (cARDS) t...
Clinical Studies - Oct 19, 2021 - Dec 31, 2022
Automatically Closed
Project leader: Göhl-Freyn Kristina, Felbecker Ansgar
Members: Toller Gianina, Albrich Werner, Schmid Dagmar, Kleger Gian-Reto, Schrag Claudia, Pietsch Urs
Covid 19 Impfantwort, Bedarf und Reaktion auf mögliche Booster- Impfung bei Patienten mit soliden Neoplasien
Oct 1, 2021Patienten mit malignen Erkrankungen stellen eine durch die SARS-CoV-2-Pandemie hoch gefährdete Gruppe dar mit einem hohen Hospitalisations- und Mortalitätsrisiko. Eine Impfung gegen SARS-COV2 stellt neben allgemeinen Schutzmassnahmen das wichtigste E...
Clinical Studies - Oct 1, 2021 - Feb 28, 2021
Automatically Closed
Project leader: Fischer Stefanie
Members: Silzle Tobias, Demmer-Steingruber Ruth, Albrich Werner, Kahlert Christian
Resistance Development in Escherichia coli at different pH following Delafloxacin and Ciprofloxacin Challenge
Jan 1, 2021Delafloxacin , a novel dual-targeting non-zwitterionic fluoroquinolone, has received approval by the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for the treatment of acute bacterial skin and skin structure infectio...
Fundamental Research - Jan 1, 2021 - Jan 1, 2023
Automatically Closed
Project leader: Babouee Flury Baharak
SURPRISE+: SURveillance of infectious diseases among health PRofessionals In SwitzErland – a longitudinal, multicentre cohort
Sep 1, 2020In this multicentre healthcare worker cohort, we are studying risk factors, humoral immunity and long COVID symptoms in healthcare workers from 9 healthcare systems from Eastern and Northern Switzerland.
Healthcare Research - Sep 1, 2020 - Dec 31, 2023
Ongoing
Project leader: Kohler Philipp
CRiPSI/CRiPSI-X: Covid-19 Risk Prediction in Swiss ICUs-Trial/Extension
Aug 1, 2020Outcome of patients with critical Covid-19 varies. We study risk of and predictors for poor outcome in adult patients with Covid-19 admitted to ICU in a multicenter study. In addition, we assess the prevalence of, risk factors for and mechanisms invo...
Clinical Studies - Aug 1, 2020 - Aug 31, 2022
Automatically Closed
Project leader: Albrich Werner
Members: Von Mering Christian, O'Mahony Liam, Cerny Andreas, Suh Noémie, El Baz Yassir, Dietrich Tobias, Fischer Tim, Felbecker Ansgar, Göhl-Freyn Kristina, Germann Nicolas, Schmid Dagmar, Kahlert Christian, Frischknecht Manuel, Filipovic Miodrag, Brutsche Martin, Pietsch Urs, Kleger Gian-Reto, Bochud Pierre-Yves
Metabolism of antiretroviral drugs in HIV infected patients with toxicity – a pilot study
Jan 1, 2020Antiretroviral drugs can be responsible for a wide range of toxic side effects ranging from acute events to long-term toxicity. We hypothesize that the microbiome-mediated metabolism plays a substantial role in antiretroviral drug toxicity through se...
Clinical Studies - Jan 1, 2020 - Dec 31, 2020
Automatically Closed
Project leader: Notter Julia, Zimmermann Michael, Kahlert Christian
Multi-omic Approach with Genome editing to unravel the Resistance Mechanisms to Ceftazidime Avibactam in Pseudomonas aeruginosa,
Jun 20, 2019In this study, a collaborative work with EMBL Heidelberg, ETH- D BSSE Empa (Materials Science and Technology), we deciphered –hitherto unknown- resistance mechanisms of P. aeruginosa to ceftazidime- avibactam (CZA), a novel antibiotic with a multi-o...
Fundamental Research - Jun 20, 2019 - Jan 1, 2023
Automatically Closed
Project leader: Babouee Flury Baharak, Kogadeeva-Zimmermann Maria
First Experiences with Screening of Anal Intraepithelial Neoplasia (AIN): a Single Center Retrospective Data-Analysis
Sep 1, 2017Hintergrund Zwischen Human Papilloma Virus (HPV) und Analkrebs besteht eine starke Korrelation. Wie beim Cervixkarzinom der Frau sind mehr als 80% der Analkarzinome durch HPV bedingt. Analkrebs geht meist aus Vorläuferläsionen, den analen intraepithe...
Clinical Studies - Sep 1, 2017 - Sep 2, 2018
Automatically Closed
Project leader: Baumeler Stephan
Members: Maurus Christine, Marti Lukas, Borovicka Jan, Bock Susanne, Bischofberger Stephan, Schmid Patrick
Biofilms on short-term indwelling ureteral stents: Influence on associated symptoms and complications; Prediction by urine analysis; Current bacterial spectrum and antibiotic resistance
Oct 10, 2015Die Einlage von Harnleiterschienen ist im urologischen Alltag unverzichtbar. Sie ist jedoch mit erheblichen Beschwerden und Komplikationen verbunden. Die Möglichkeiten diese zu reduzieren sind beschränkt. Mit zunehmender Einlagedauer von Harnleitersc...
Clinical Studies - Oct 10, 2015 - Feb 10, 2018
Automatically Closed
Project leader: Abt Dominik
Members: Zumstein Valentin, Betschart Patrick, Qun Ren, Buhmann Matthias, Schmid Hans-Peter, Engeler Daniel, Albrich Werner
STD4free
Jan 1, 2015Studie zur Evaluation einer optimalen Teststrategie auf die wichtigsten sexuell übertragbaren Erkrankungen (STD) bei symptomfreien Personen
Clinical Studies - Jan 1, 2015 - Dec 31, 2015
Automatically Closed
Project leader: Vernazza Pietro
Clinical impact of multiplex realtime PCR in respiratory tract infections
Nov 15, 2014Pathogen detection in respiratory tract infections is challenging due to lack of diagnostic gold standard with sufficient sensitivity and specificity. Viral infections likely contribute to a considerable portion of respiratory tract infections partic...
Clinical Studies - Nov 15, 2014 - Dec 31, 2015
Automatically Closed
Project leader: Albrich Werner
Members: Kahlert Christian, Rassouli Frank, Mayer Lena
Airway microbiota resistome in CF - impact on clinical management
Sep 1, 2014Cystic Fibrosis is a deadly genetic disease mainly due to chronic bacterial colonization and recurrent bacterial infections of the lungs. It has often been documented that once a certain microbial species such as Pseudomonas aeruginosa establishes, t...
Fundamental Research - Sep 1, 2014 - Dec 31, 2016
Automatically Closed
Project leader: Baty Florent
Members: Brutsche Martin, Kahlert Christian, Von Mering Christian, Vyas Rounak
Human airway epithelia and pneumococcus. Polarized in vitro cell culture model to study interaction between human airway epithelia and pneumococcus
Jan 1, 2014This project aims to extend the existing human airway epithelial model to enable studies on the most relevant and lethal respiratory bacterial pathogen, Streptococcus pneumoniae (SP). The primary goal of this proposal is to show the feasibility of th...
Fundamental Research - Jan 1, 2014 - Dec 31, 2014
Automatically Closed
Project leader: Albrich Werner, Kahlert Christian
Positive Deviance in der Hepatitis C Behandlung
Nov 15, 2013Hepatitis C ist eine durch Blut übertragbare, infektiöse Leberentzündung, die durch das Hepatitis C Virus (HCV) hervorgerufen wird. Durch eine antivirale Behandlung können ernsthafte und behandlungsintensive Spätfolgen der Hepatitis C wie die Leberzi...
Clinical Studies - Nov 15, 2013 - Feb 28, 2015
Automatically Closed
Project leader: Nicca Dunja
Members: Vernazza Pietro, Rasi Manuela, Scharf Regina, Brugmann Philip, Fehr Jan
Unravelling the Evil - the role of CXCL-10 antagonist in HIV+ failing immune recovery despite cART
Jul 1, 2013Although highly active antiretroviral therapy (HAART) leads in general to CD4+ T-cell recovery and decrease of general immune activation, therefore improving individuals’ long-term prognosis, in a clinically significant percentage of 20% of HIV-infec...
Fundamental Research - Jul 1, 2013 - Apr 30, 2014
Automatically Closed
Project leader: Hoffmann Matthias
Members: Schmid Patrick, Kahlert Christian, Vernazza Pietro