Publication
Decision-Making Analysis for Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer: A Survey by the Executive Committee of the Peritoneal Surface Oncology Group International (PSOGI)
Journal Paper/Review - Sep 11, 2020
Steffen Thomas, Yutaka Yonemura, Paul Sugarbaker, Beate Rau, Quadros Claudio A, Pompiliu Piso, Morris David L, Moran Brendan J, Yan Li, Ignace de Hingh, Goere Diane, Glehen Olivier, Glatzer Markus, Lana Bijelic, Häller Lukas, Putora Paul Martin
Units
Keywords
Aged
*Clinical Decision-Making
Combined Modality Therapy
Cytoreduction Surgical Procedures/methods
Female
Humans
*Hyperthermic Intraperitoneal Chemotherapy
Middle Aged
Neoplasm Recurrence, Local/drug therapy/pathology/surgery
Ovarian Neoplasms/*drug therapy/epidemiology/pathology/surgery
Peritoneal Neoplasms/*drug therapy/epidemiology/pathology
Treatment Outcome
Chemotherapy
Hyperthermic intraperitoneal chemotherapy
Metastasis
Ovarian cancer
Peritoneal carcinomatosis
Peritoneal malignancy
PubMed
Doi
Contact
Citation
Type
Journal
Publication Date
Issn Print
Issn Electronic
Pages
Brief description/objective
OBJECTIVES
To assess the individual treatment strategies among international experts in peritoneal carcinosis, specifically their decision-making in the process of patient selection for hyperthermic intraperitoneal chemotherapy (HIPEC) in women suffering from ovarian cancer, to identify relevant decision-making criteria, and to quantify the level of consensus for or against HIPEC.
METHODS
The members of the executive committee of the Peritoneal Surface Oncology Group International (PSOGI) were asked to describe the clinical conditions under which they would recommend HIPEC in patients with ovarian cancer and to describe any disease or patient characteristics relevant to their decision. All answers were then merged and converted into decision trees. The decision trees were then analyzed by applying the objective consensus methodology.
RESULTS
Nine experts in surgical oncology provided information on their multidisciplinary treatment strategy including HIPEC for patients with advanced ovarian cancer. Three of the total of 12 experts did not perform HIPEC. Five criteria relevant to the decision on whether HIPEC is performed were applied. In patients with resectable disease, a peritoneal cancer index (PCI) <21, and epithelial ovarian cancer without distant metastasis, consent was received by 75% to perform HIPEC for women suffering from recurrent disease. Furthermore, in the primary disease setting, consent was received by 67% to perform HIPEC according to the same criteria.
DISCUSSION AND CONCLUSION
Among surgical oncology experts in peritoneal surface malignancy and HIPEC, HIPEC plays an important role in primary and recurrent ovarian cancer, and the PCI is the most important criterion in this decision.