Implications of a positive sentinel node in oral squamous cell carcinoma

Publication

Implications of a positive sentinel node in oral squamous cell carcinoma

Journal Paper/Review - Jan 31, 2012

McGurk Mark, Zuazua J Santamaria, Ross Gary L, Rahimi Siavash, Poli Tito, O'Doherty Michael J, Odell Edward W, Mastronicola Romina, Silini Enrico M, Mamelle Gerard, Santini Simone, Sebbesen Lars, Shoaib Taimur, Wiegand Susanne, Werner Jochen A, von Buchwald Christian, Villarreal Pedro M, Vigili Maurizio Giovanni, Therkildsen Marianne H, Soutar David S, Sorensen Jens Ahm, Sloan Philip, Lothaire Phillippe H, Leroux Agnes, Lawson George, Bloemena Elisabeth, Bilde Anders, Barzan Luigi, Barbier Herrero Luis, Bakholdt Vivi, Alvarez Amezaga J, Alkureishi Lee W, Putcha Venkata, Schilling Clare, Salces Carmen Camarero, Dalla Palma Paolo, de Bree Remco, Hunter Keith, Huber Gerhard, Haerle Stephan, Grandi Cesare, Fresno Manuel, Flach Géke B, Donner Davide, Dolivet Gilles, Dequanter Didier, Gurney Benjamin A S

Citation

McGurk M, Zuazua J, Ross G, Rahimi S, Poli T, O'Doherty M, Odell E, Mastronicola R, Silini E, Mamelle G, Santini S, Sebbesen L, Shoaib T, Wiegand S, Werner J, von Buchwald C, Villarreal P, Vigili M, Therkildsen M, Soutar D, Sorensen J, Sloan P, Lothaire P, Leroux A, Lawson G, Bloemena E, Bilde A, Barzan L, Barbier Herrero L, Bakholdt V, Alvarez A, Alkureishi L, Putcha V, Schilling C, Salces C, Dalla Palma P, de Bree R, Hunter K, Huber G, Haerle S, Grandi C, Fresno M, Flach G, Donner D, Dolivet G, Dequanter D, Gurney B. Implications of a positive sentinel node in oral squamous cell carcinoma. Head & neck 2012; 34:1580-5.

Type

Journal Paper/Review (English)

Journal

Head & neck 2012; 34

Publication Date

Jan 31, 2012

Issn Electronic

1097-0347

Pages

1580-5

Brief description/objective

BACKGROUND
The role of sentinel node biopsy in head and neck cancer is currently being explored. Patients with positive sentinel nodes were investigated to establish if additional metastases were present in the neck, their distribution, and their impact on outcome.

METHODS
In all, 109 patients (n = 109) from 15 European centers, with cT1/2,N0 tumors, and a positive sentinel lymph node were identified. Kaplan-Meier and univariate and multivariate logistic regression analysis were used to identify variables that predicted for additional positive nodes and their position within the neck.

RESULTS
A total of 122 neck dissections were performed in 109 patients. Additional positive nodes were found in 34.4% of cases (42/122: 18 same, 21 adjacent, and 3 nonadjacent neck level). Additional nodes, especially if outside the sentinel node basin, had an impact on outcome.

CONCLUSIONS
The results are preliminary but suggest that both the number and the position of positive sentinel nodes may identify different prognostic groups that may allow further tailoring of management plans.