Publication
Consensus Statement on Circulating Biomarkers for Advanced Prostate Cancer
Journal Paper/Review - May 15, 2018
Sumanasuriya Semini, Luo Jun, Mehra Niven, Olmos David, Scher Howard, Soule Howard, Stoecklein Nikolas H, Terstappen Leon W M M, Waugh David, Lorente David, Lolkema Martijn, Omlin Aurelius, Armstrong Andrew, Attard Gerhardt, Chi Kim N, Bevan Charlotte L, Shibakawa Aki, IJzerman Maarten J, De Laere Bram, de Bono Johann S
Units
PubMed
Doi
Citation
Type
Journal
Publication Date
Issn Electronic
Pages
Brief description/objective
CONTEXT
In advanced prostate cancer (PC), there is increasing investigation of circulating biomarkers, including quantitation and characterization of circulating tumour cells and cell-free nucleic acids, for therapeutic monitoring and as prognostic and predictive biomarkers. However, there is a lack of consensus and standardisation regarding analyses, reporting, and integration of results into specific clinical contexts. A consensus meeting on circulating biomarkers was held to address these topics.
OBJECTIVE
To present a report of the consensus statement on circulating biomarkers in advanced PC.
EVIDENCE ACQUISITION
Four important areas of controversy in the field of circulating biomarkers in PC management were identified: known clinical utility of circulating biomarkers; unmet clinical needs for circulating biomarkers in PC care; most pressing blood-based molecular assays required; and essential steps for developing circulating biomarker assays. A panel of 18 international PC experts in the field of circulating biomarkers developed the programme and consensus questions. The panel voted publicly but anonymously on 50 predefined questions developed following a modified Delphi process.
EVIDENCE SYNTHESIS
Voting was based solely on panellist opinions of the predefined topics and therefore not on a standard literature review or meta-analysis. The outcomes of the voting had varying degrees of support, as reflected in the wording of this article and in the detailed voting results provided in the Supplementary material.
CONCLUSIONS
The expert voting results presented can guide the future development of circulating biomarkers for PC care. Notably, the consensus meeting highlighted the importance of reproducibility and variability studies, among other significant areas in need of trials specifically designed to address them.
PATIENT SUMMARY
A panel of international experts met to discuss and vote on the use of different blood-based prostate cancer tests, and how they can be used to guide treatment and disease monitoring to deliver more precise and better patient care.