Do human tumor-associated viruses play a role in the development of synovial sarcoma?

Publication

Do human tumor-associated viruses play a role in the development of synovial sarcoma?

Journal Paper/Review - Apr 15, 2015

Lenze Ulrich, Pohlig Florian, Mühlhofer Heinrich, Lenze Florian, Toepfer Andreas, Rechl Hans, Burgkart Rainer, von Eisenhart-Rothe Rüdiger, Straub Melanie

Citation

Lenze U, Pohlig F, Mühlhofer H, Lenze F, Toepfer A, Rechl H, Burgkart R, von Eisenhart-Rothe R, Straub M. Do human tumor-associated viruses play a role in the development of synovial sarcoma?. Clin Sarcoma Res 2015; 5:11.

Type

Journal Paper/Review (English)

Journal

Clin Sarcoma Res 2015; 5

Publication Date

Apr 15, 2015

Issn Print

2045-3329

Brief description/objective

BACKGROUND
To date, the pathomechanism of soft tissue sarcomas such as synovial sarcoma remains unclear whereas even a viral etiology was suspected. Aim of this study was to analyze whether EBV, HHV-8 or HPV play a role in the development of synovial sarcomas.

FINDINGS
In total 41 synovial sarcomas were included in this retrospective study. For detection of EBV 1/2 and HHV-8, resection specimens were analyzed with regard to virus-specific sequences using a SingleStep PCR. HPV analysis was carried out by an HPV-specific multiplex-PCR and subsequent array-hybridization for HPV-typing. No virus-specific DNA of EBV, HHV-8 or HPV was detected.

CONCLUSION
An involvement of these viruses in the etiology of synovial sarcoma was not detected but further studies are needed with different virus types and sarcoma entities.