Publication
Hepatosplenic T-cell lymphoma in a patient with Crohn's disease
Journal Paper/Review - Jul 1, 2009
Beigel Florian, Jürgens Matthias, Tillack Cornelia, Subklewe Marion, Mayr Doris, Göke Burkhard, Brand Stephan, Ochsenkühn Thomas
Units
PubMed
Doi
Citation
Type
Journal
Publication Date
Issn Electronic
Pages
Brief description/objective
BACKGROUND
A 58-year-old man who had a 35-year history of Crohn's disease presented to our IBD center with a disease flare, pararectal fistulas and abscess formation. The patient had previously undergone ileocolic resection for a stenosis and his abscesses had been treated by surgical drainage. He had been taking azathioprine therapy for approximately 5.5 years and had received high-dose steroids. He had also previously taken metronidazole and antihypertensive medications.
INVESTIGATIONS
Physical examination, laboratory investigations including hemoglobin levels and white blood cell counts, genetic testing, CT, bone-marrow biopsy, immunophenotyping by fluorescence-activated cell sorting, polymerase chain reaction analyses, fluorescence in situ hybridization, sputum culture and diagnostic splenectomy.
DIAGNOSIS
Hepatosplenic T-cell lymphoma.
MANAGEMENT
Splenectomy, antibiotic therapy and chemotherapy with cyclophosphamide.