Vitamin E inhibits proliferation of human Tenon's capsule fibroblasts in vitro

Publication

Vitamin E inhibits proliferation of human Tenon's capsule fibroblasts in vitro

Journal Paper/Review - Jan 1, 1996

Haas A L, Boscoboinik D, Mojon Daniel, Böhnke M, Azzi A

Units

Department of Ophthalmology

PubMed

8829174

Citation

Haas A, Boscoboinik D, Mojon D, Böhnke M, Azzi A. Vitamin E inhibits proliferation of human Tenon's capsule fibroblasts in vitro. Ophthalmic research 1996; 28:171-5.

Type

Journal Paper/Review (English)

Journal

Ophthalmic research 1996; 28

Publication Date

Jan 1, 1996

Issn Print

0030-3747

Pages

171-5

Brief description/objective

Failure of glaucoma surgery is mostly due to fibrocellular scar formation, derived from Tenon's capsule fibroblasts. In high-risk cases, postoperative Tenon's capsule fibroblast proliferation is inhibited by mitomycin C or 5-fluorouracil. Toxicity to other ocular cell types and the risk of ocular hypotony limits the use of these agents. We have found that d-alpha-tocopherol (vitamin E) was able to inhibit proliferation of in vitro human Tenon's capsule fibroblasts obtained from seven different donors. At 48 h, inhibition of cell proliferation was 30-78% (mean 60%) for 50 microM d-alpha-tocopherol and 46-97% (mean 77%) for 100 microM d-alpha-tocopherol. This inhibition was statistically significant. No cytotoxic effects were observed.