Publication

Nodular malignant melanoma and multiple cutaneous neoplasms under immunosuppression with azathioprine

Journal Paper/Review - Aug 1, 2009

Units
PubMed
Doi

Citation
Guenova E, Lichte V, Hoetzenecker W, Woelbing F, Moehrle M, Roecken M, Schaller M. Nodular malignant melanoma and multiple cutaneous neoplasms under immunosuppression with azathioprine. Melanoma Res 2009; 19:271-3.
Type
Journal Paper/Review (English)
Journal
Melanoma Res 2009; 19
Publication Date
Aug 1, 2009
Issn Electronic
1473-5636
Pages
271-3
Brief description/objective

Immunosuppressed patients are at increased risk of skin cancer. A 67-year-old renal transplant recipient developed a nodular malignant melanoma after 30 years of immunosuppression with azathioprine and prednisolone. The patient died of metastatic disease 3 months after the diagnosis was made. The function of the renal graft was not affected at all. Renal transplant recipients are at high risk of developing nonmelanocytic skin tumors when on immunosuppressive therapy with cyclosporine A. Less common is the development of skin cancer during immunosuppression with azathioprine. Latest reports show the increased incidence of malignant melanoma in immunosuppressed patients. Our case illustrates the necessity of close dermatological surveillance of allograft recipients, to assure an early recognition of any malignant skin tumor and to reduce the risk of systemic metastatic disease.