Publication

Treatment of pyoderma gangrenosum with topical factor XIII

Journal Paper/Review - Sep 1, 2013

Units
PubMed
Doi

Citation
Hoetzenecker W, Guenova E, Mitev V, Schanz S, Ulmer A, Fierlbeck G. Treatment of pyoderma gangrenosum with topical factor XIII. Eur J Dermatol 2013; 23:653-7.
Type
Journal Paper/Review (English)
Journal
Eur J Dermatol 2013; 23
Publication Date
Sep 1, 2013
Issn Electronic
1952-4013
Pages
653-7
Brief description/objective

Pyoderma gangrenosum (PG) is a severe ulcerative skin disease. Despite systemic immunosuppressive therapy, PG ulcers often progress and can develop into life-threatening conditions. In this case series, we treated 6 patients suffering from recalcitrant PG with topical coagulation factor XIII, which has been shown to exert beneficial effects on tissue regeneration and wound healing. All 6 patients showed a positive response to treatment with a marked reduction in wound size that was maintained during a 3-month follow-up period. The treatment was well tolerated with no remarkable adverse effects or complications. Topical factor XIII has potential in combination with standard immunosuppressive therapy for the treatment of PG.