[Brown urine : Myoglobin-induced renal failure after concomitant administration of simvastatin and amiodarone]

Publication

[Brown urine : Myoglobin-induced renal failure after concomitant administration of simvastatin and amiodarone]

Journal Paper/Review - May 3, 2016

Pietsch Urs, Müller-Höcker C, Filipovic Miodrag

Citation

Pietsch U, Müller-Höcker C, Filipovic M. [Brown urine : Myoglobin-induced renal failure after concomitant administration of simvastatin and amiodarone]. Anaesthesist 2016; 65:366-8.

Type

Journal Paper/Review (Deutsch)

Journal

Anaesthesist 2016; 65

Publication Date

May 3, 2016

Issn Electronic

1432-055X

Pages

366-8

Brief description/objective

Rhabdomyolysis is a rare but well-known complication of statin therapy. The risk is considerably increased when concomitant drugs are administered that inhibit metabolism and breakdown via the cytochrome CYP3A4. We report a case of myoglobin-induced acute renal failure secondary to the concomitant use of simvastatin and amiodarone. The risk of rhabdomyolysis is mainly determined by the statin dose; in the case of the concomitant use of CYP3A4 inhibitors, a maximal daily dose of 20 mg is recommended to avoid harmful drug interactions.