Hyppercalcemic type of the small cell carcinoma of the ovary: Characterization of a new tumor line

Publication

Hyppercalcemic type of the small cell carcinoma of the ovary: Characterization of a new tumor line

Journal Paper/Review - Jan 2, 2001

Hornung René, Fink D., Dobler-Girdziunaite D, Stallmach Th, Spycher MA, Maly F., Haller Urs, Bürki N

Citation

Hornung R, Fink D, Dobler-Girdziunaite D, Stallmach T, Spycher M, Maly F, Haller U, Bürki N. Hyppercalcemic type of the small cell carcinoma of the ovary: Characterization of a new tumor line. Anticancer Res 2001; 21:3253-3259.

Type

Journal Paper/Review (English)

Journal

Anticancer Res 2001; 21

Publication Date

Jan 2, 2001

Pages

3253-3259

Brief description/objective

BACKGROUND: The aim of this study was to develop and characterize a mouse xenograft model for the hypercalcemic-type of small cell carcinoma of the ovary (HTSCCO). PATIENTS AND METHODS: Tumor fragments were removed from a patient and cultured in six subsequent generations of nude mice. Histology, comparative genomic hybridization (CGH), electron microscopy and serum calcium levels were investigated.

RESULTS: Morphology remained the same from the primary tumor of the patient through the 6th passage in the mouse. Serum calcium levels were significantly higher in the tumor-bearing mice compared to controls. CGH of the HTSCCO did not show evidence of a close relationship to either a germ cell tumor or an epithelial ovarian cancer.

CONCLUSION: Some evidence was provided that the HTSCCO is an inhomogeneous tumor that is neither related to a germ cell tumor nor to an epithelial ovarian cancer, but is a distinct tumor entity.