Histopathological features and their prognostic impact in nodular lymphocyte-predominant Hodgkin lymphoma--a matched pair analysis from the German Hodgkin Study Group (GHSG)

Publication

Histopathological features and their prognostic impact in nodular lymphocyte-predominant Hodgkin lymphoma--a matched pair analysis from the German Hodgkin Study Group (GHSG)

Journal Paper/Review - Jun 26, 2014

Hartmann Sylvia, Engert Andreas, Hansmann Martin-Leo, Stein Harald, Rosenwald Andreas, Möller Peter, Ott German, Feller Alfred C, Hummel Michael, Cogliatti Sergio B., Bernd Heinz-Wolfram, Koch Karoline, Bob Roshanak, Mottok Anja, Plütschow Annette, Eichenauer Dennis A, Klapper Wolfram

Citation

Hartmann S, Engert A, Hansmann M, Stein H, Rosenwald A, Möller P, Ott G, Feller A, Hummel M, Cogliatti S, Bernd H, Koch K, Bob R, Mottok A, Plütschow A, Eichenauer D, Klapper W. Histopathological features and their prognostic impact in nodular lymphocyte-predominant Hodgkin lymphoma--a matched pair analysis from the German Hodgkin Study Group (GHSG). Br J Haematol 2014; 167:238-42.

Type

Journal Paper/Review (English)

Journal

Br J Haematol 2014; 167

Publication Date

Jun 26, 2014

Issn Electronic

1365-2141

Pages

238-42

Brief description/objective

Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare lymphoma entity. We performed a matched-pair analysis to evaluate the prognostic impact of several histopathological features in this distinct Hodgkin lymphoma subtype. Lymph node samples of NLPHL patients were tested for CD15, IgD, phosphorylated STAT6, ICOS and Epstein-Barr virus status of the malignant lymphocyte-predominant cells as well as epithelioid cell clusters and activated T cells in the microenvironment. None of these features was associated with a particular clinical outcome. However, patients presenting with epithelioid cell clusters showed a non-significant trend towards a lower relapse rate, justifying further evaluation of this marker.