Publication

Hypogonadism in HIV-1-infected men is common and does not resolve during antiretroviral therapy

Journal Paper/Review - Jan 1, 2007

Units
PubMed

Citation
Wunder D, Furrer H, Mueller B, Bernasconi E, Schmid P, Elzi L, Cavassini M, Hirschel B, Mueller N, Fux C, Bersinger N, Swiss HIV Cohort Study. Hypogonadism in HIV-1-infected men is common and does not resolve during antiretroviral therapy. Antiviral therapy 2007; 12:261-5.
Type
Journal Paper/Review (English)
Journal
Antiviral therapy 2007; 12
Publication Date
Jan 1, 2007
Issn Print
1359-6535
Pages
261-5
Brief description/objective

OBJECTIVES: To assess the prevalence of abnormal testosterone and gonadotropin values in HIV-infected men before and after 2 years of combination antiretroviral therapy (cART). DESIGN: Multicentre cohort of HIV-infected adults. METHODS: We identified 139 Caucasian antiretroviral-naive male patients who started zidovudine/ lamivudine-based cART that was virologically successful over a 2 year period. Ninety-seven were randomly chosen and plasma hormone determinations of free testosterone (fT) and luteinizing hormone (LH) at baseline and after 2 years of cART were evaluated. RESULTS: At baseline 68 patients (70%) had subnormal fT levels. In these, LH levels were low in 44%, normal in 47% and high in 9%. There was a trend for an association between lower CD4+ T-cell counts and hypogonadism. Most participants had normal FSH levels. No significant changes of fT, LH and FSH levels were observed after 2 years of cART. CONCLUSIONS: Low fT levels, mainly with normal or low LH levels and thus indicating secondary hypogonadism, are found in the majority of HIV-infected men and do not resolve during 2 years of successful cART.