Autoimmunity seen through the SEREX-scope

Publication

Autoimmunity seen through the SEREX-scope

Journal Paper/Review - Oct 1, 2003

Krebs Philippe, Kurrer Michael, Sahin Ugur, Türeci Ozlem, Ludewig Burkhard

Units

Medizinisches Forschungszentrum, Institute of Immunobiology

PubMed

14550875

Citation

Krebs P, Kurrer M, Sahin U, Türeci O, Ludewig B. Autoimmunity seen through the SEREX-scope. Autoimmunity reviews 2003; 2:339-45.

Type

Journal Paper/Review (English)

Journal

Autoimmunity reviews 2003; 2

Publication Date

Oct 1, 2003

Issn Print

1568-9972

Pages

339-45

Brief description/objective

Autoantibodies can be detected in autoimmune diseases with a long prodromal phase and may serve as early indicators of disease activity. Autoantibody-based screening methods are therefore potent tools for the identification of target antigens. The SEREX method (serological identification of antigens by recombinant expression cloning) has been developed for the serological definition of immunogenic tumor antigens. Recent studies indicate that the SEREX approach may also be utilized for the analysis of complex immune responses involved in autoimmune diseases.