Expression and activity of the cytochrome P450 2E1 in patients with nonalcoholic steatosis and steatohepatitis

Publication

Expression and activity of the cytochrome P450 2E1 in patients with nonalcoholic steatosis and steatohepatitis

Journal Paper/Review - Aug 1, 2007

Chtioui Haithem, Semela David, Ledermann Monika, Zimmermann Arthur, Dufour Jean-François

Citation

Chtioui H, Semela D, Ledermann M, Zimmermann A, Dufour J. Expression and activity of the cytochrome P450 2E1 in patients with nonalcoholic steatosis and steatohepatitis. Liver Int 2007; 27:764-71.

Type

Journal Paper/Review (English)

Journal

Liver Int 2007; 27

Publication Date

Aug 1, 2007

Issn Print

1478-3223

Pages

764-71

Brief description/objective

Nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver (NAFL) have a different prognosis and should be dealt with differently. The pathogenesis of NASH implicates the overexpression of cytochrome P450 2E1 (CYP2E1). We investigated whether the noninvasive determination of CYP2E1 activity could replace a liver biopsy in order to differentiate NASH from NAFL.