Study of the time course of the clinical effect of propofol compared with the time course of the predicted effect-site concentration: Performance of three pharmacokinetic-dynamic models

Publication

Study of the time course of the clinical effect of propofol compared with the time course of the predicted effect-site concentration: Performance of three pharmacokinetic-dynamic models

Journal Paper/Review - Feb 26, 2010

Coppens M, Van Limmen J G M, Schnider Thomas, Wyler B, Bonte S, Dewaele F, Struys M M R F, Vereecke H E M

Citation

Coppens M, Van Limmen J, Schnider T, Wyler B, Bonte S, Dewaele F, Struys M, Vereecke H. Study of the time course of the clinical effect of propofol compared with the time course of the predicted effect-site concentration: Performance of three pharmacokinetic-dynamic models. Br J Anaesth 2010; 104:452-8.

Type

Journal Paper/Review (English)

Journal

Br J Anaesth 2010; 104

Publication Date

Feb 26, 2010

Issn Electronic

1471-6771

Pages

452-8

Brief description/objective

In the ideal pharmacokinetic-dynamic (PK-PD) model for calculating the predicted effect-site concentration of propofol (Ce(PROP)), for any Ce(PROP), the corresponding hypnotic effect should be constant. We compared three PK-PD models (Marsh PK with Shüttler PD, Schnider PK with fixed ke0, and Schnider PK with Minto PD) in their ability to maintain a constant bispectral index (BIS), while using the respective effect-site-controlled target-controlled infusion (TCI) algorithms.