Publication

No longitudinal mitochondrial DNA sequence changes in HIV-infected individuals with and without lipoatrophy

Journal Paper/Review - Jan 12, 2011

Units
PubMed
Doi

Citation
Ortiz M, Tarr P, Telenti A, Günthard H, Ledergerber B, Cavassini M, Hirschel B, Vernazza P, Bernasconi E, Elzi L, Arnedo M, Martinez R, Kovari H, Furrer H, Poloni E, Swiss HIV Cohort Study. No longitudinal mitochondrial DNA sequence changes in HIV-infected individuals with and without lipoatrophy. J Infect Dis 2011; 203:620-4.
Type
Journal Paper/Review (English)
Journal
J Infect Dis 2011; 203
Publication Date
Jan 12, 2011
Issn Electronic
1537-6613
Pages
620-4
Brief description/objective

The potential for mitochondrial (mt) DNA mutation accumulation during antiretroviral therapy (ART), and preferential accumulation in patients with lipoatrophy compared with control participants, remains controversial. We sequenced the entire mitochondrial genome, both before ART and after ART exposure, in 29 human immunodeficiency virus (HIV)-infected Swiss HIV Cohort Study participants initiating a first-line thymidine analogue-containing ART regimen. No accumulation of mtDNA mutations or deletions was detected in 13 participants who developed lipoatrophy or in 16 control participants after significant and comparable ART exposure (median duration, 3.3 and 3.7 years, respectively). In HIV-infected persons, the development of lipoatrophy is unlikely to be associated with accumulation of mtDNA mutations detectable in peripheral blood.