Precursor B lymphoblastic leukemia 32 months after local therapy for a primary extramedullary myeloid cell tumor

Publication

Precursor B lymphoblastic leukemia 32 months after local therapy for a primary extramedullary myeloid cell tumor

Journal Paper/Review - Dec 1, 2007

Szinnai Gabor, Cogliatti Sergio B., Avoledo Pierino, Dirnhofer Stephan, Schmid Ulrico, Kühne Thomas

Citation

Szinnai G, Cogliatti S, Avoledo P, Dirnhofer S, Schmid U, Kühne T. Precursor B lymphoblastic leukemia 32 months after local therapy for a primary extramedullary myeloid cell tumor. Pediatr Blood Cancer 2007; 49:1039-46.

Type

Journal Paper/Review (English)

Journal

Pediatr Blood Cancer 2007; 49

Publication Date

Dec 1, 2007

Issn Print

1545-5009

Pages

1039-46

Brief description/objective

A primary extramedullary myeloid cell tumor (pEMT) of an inguinal lymph node was completely excised without subsequent anti-tumor therapy in a 6-year-old child. Clinical observation and monitoring of blood and bone marrow (BM) did not reveal any pathologic results before 32 months, when a precursor B lymphoblastic leukemia was diagnosed. Identical T-cell receptor gamma rearrangement in nodal pEMT and in precursor B lymphoblastic leukemia in BM indicates a clonal relationship of these two tumors.