Predictors of long-term mortality and cardiac events in patients with known or suspected coronary artery disease who survive major non-cardiac surgery

Publication

Predictors of long-term mortality and cardiac events in patients with known or suspected coronary artery disease who survive major non-cardiac surgery

Journal Paper/Review - Jan 1, 2005

Filipovic Miodrag, Jeger R V, Girard T, Probst C, Pfisterer M, Gürke L, Studer W, Seeberger M D

Citation

Filipovic M, Jeger R, Girard T, Probst C, Pfisterer M, Gürke L, Studer W, Seeberger M. Predictors of long-term mortality and cardiac events in patients with known or suspected coronary artery disease who survive major non-cardiac surgery. Anaesthesia 2005; 60:5-11.

Type

Journal Paper/Review (English)

Journal

Anaesthesia 2005; 60

Publication Date

Jan 1, 2005

Issn Print

0003-2409

Pages

5-11

Brief description/objective

The aim of this prospective study was to assess predictors of long-term outcome in patients with documented or suspected coronary artery disease who survive major non-cardiac surgery. The impact of patients' comorbidities, pre-operative heart rate variability and postoperative increase in cardiac troponin I on all-cause mortality and major cardiac events within 2 years was explored using multivariable logistic regression. Six of 173 patients died within the first month after surgery and were excluded from the study. Thirty-four of 167 patients (20%) died 1-24 months after surgery. Independent predictors of all-cause mortality were history of congestive heart failure (odds ratio 6.4 [95%, confidence interval 1.7-24]), pre-operatively depressed heart rate variability (odds ratio 6.4 [95%, confidence interval 1.9-21]), and age > 70 years (odds ratio 4.5 [95%, confidence interval 1.2-16]). In contrast, postoperative elevation of cardiac troponin I did not independently predict all-cause mortality or major cardiac events.