Effects of dopexamine in a rat model of supracoeliac aortic cross-clamping and declamping

Publication

Effects of dopexamine in a rat model of supracoeliac aortic cross-clamping and declamping

Journal Paper/Review - Jan 1, 2006

Studer W, Wu X, Siegemund M, Seeberger M, Filipovic Miodrag

Citation

Studer W, Wu X, Siegemund M, Seeberger M, Filipovic M. Effects of dopexamine in a rat model of supracoeliac aortic cross-clamping and declamping. European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes 2006; 38:63-9.

Type

Journal Paper/Review (English)

Journal

European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes 2006; 38

Publication Date

Jan 1, 2006

Issn Print

0014-312X

Pages

63-9

Brief description/objective

This experimental study in rats was designed to demonstrate effects of dopexamine (3 microg kg(-1) min(-1), n = 6) or physiologic saline solution (n = 6) on systemic as well as regional perfusion during 30 min of supracoeliac aortic cross-clamping and during 180 min of reperfusion following declamping. Rats were surgically instrumented with arterial, right atrial and portal venous catheters, ultrasonic flow probes around the abdominal aorta, superior mesenteric and carotid artery, and a paediatric tonometer for intestinal mucosal PCO(2) measurement. During 120 min of reperfusion, fluid resuscitation was titrated to keep abdominal aortic blood flow above 80% of baseline values. We found that during cross-clamping, values of arterial lactate (p = 0.002) and intestinal tonometric PCO(2) (p = 0.018) were higher in the dopexamine group than in the control group.