[Prognostic significance of p53 autoantibodies in serum of patients with breast carcinoma]

Publication

[Prognostic significance of p53 autoantibodies in serum of patients with breast carcinoma]

Journal Paper/Review - Jan 1, 1996

Huober Jens, Sprenger H, Costa S D, Zentgraf H, Schmid H, Kaufmann M, Bastert G

Units

Brustzentrum St.Gallen, Medizinische Onkologie und Hämatologie

PubMed

8999710

Citation

Huober J, Sprenger H, Costa S, Zentgraf H, Schmid H, Kaufmann M, Bastert G. [Prognostic significance of p53 autoantibodies in serum of patients with breast carcinoma]. Zentralblatt für Gynäkologie 1996; 118:560-4.

Type

Journal Paper/Review (Deutsch)

Journal

Zentralblatt für Gynäkologie 1996; 118

Publication Date

Jan 1, 1996

Issn Print

0044-4197

Pages

560-4

Brief description/objective

Mutations in the p53 tumor suppressor gene are the most common genetic alterations associated with malignant tumors including breast and gynecologic carcinomas. Overexpression of p53 protein is a result of increased protein stability caused through conformationally alteration. Accumulation of mutant p53 in tumor cells may lead to a humoral immune response with development of p53 autoantibodies. In the present study we investigated the sera of 72 patients undergoing surgery for primary breast cancer and the relation between p53 antibody production, prognostic parameters and clinical outcome. Circulating p53 antibodies were detected in 15 of the 72 examined patients (21%). A correlation to conventional prognostic factors was not observed. Yet the overall survival was worse in patients with p53 antibodies (p < 0.04), suggesting a more aggressive tumor type.