Publication
[Cerebral toxoplasmosis with central diabetes insipidus and panhypopituitarism in a patient with AIDS]
Journal Paper/Review - Apr 8, 1995
Brändle Michael, Vernazza Pietro, Oesterle M, Galeazzi R L
Units
PubMed
Citation
Type
Journal
Publication Date
Issn Print
Pages
Brief description/objective
Endocrine disorders in the course of HIV infection are often a result of opportunistic infections of endocrine organs. We describe the case of a 30-year-old HIV positive man in whom diabetes insipidus developed initially with no abnormal findings in cranial magnetic resonance imaging. 2 months later the patient presented with symptoms of panhypopituitarism. At this time, neuroradiologic examination was consistent with cerebral toxoplasmosis. Symptoms and neuroradiologic findings improved after treatment for cerebral toxoplasmosis. Toxoplasmosis is the most frequent opportunistic infection of the brain in patients with AIDS. In HIV positive patients with malfunction of the hypothalamic-hypophyseal system cerebral toxoplasmosis must be considered in differential diagnosis. Treatment of this disorder may alleviate symptoms and signs of endocrine malfunction.