Publication
Modulation of collagen synthesis in human glomerular epithelial cells by interleukin 1
Journal Paper/Review - Mar 1, 1989
Torbohm I, Berger B, Schönermark M, von Kempis Johannes, Rother K, Hänsch G M
Units
PubMed
Citation
Type
Journal
Publication Date
Issn Print
Pages
Brief description/objective
Human glomerular epithelial cells produce matrix material e.g. collagen type IV. In vitro, the synthesis of collagen can be monitored by the incorporation of 3H-proline, a precursor molecule of the collagens. We report on the enhancement of collagen synthesis by glomerular epithelial cells with highly purified or recombinant I1-1. Since I1-1 is released from monocytes or glomerular mesangial cells by inflammatory mediators, our results point to a participation of I1-1 in the development of sclerosis, which is seen in many forms of chronic inflammatory diseases.