New insights into the expanding complexity of the tumor suppressor ASPP2.

Publication

New insights into the expanding complexity of the tumor suppressor ASPP2.

Journal Paper/Review - Sep 8, 2009

Kampa-Schittenhelm Kerstin, Bonin Michael, Lopez Charles Darin

Citation

Kampa-Schittenhelm K, Bonin M, Lopez C. New insights into the expanding complexity of the tumor suppressor ASPP2. Cell Cycle 2009; 8:2871-6.

Type

Journal Paper/Review (English)

Journal

Cell Cycle 2009; 8

Publication Date

Sep 8, 2009

Issn Electronic

1551-4005

Pages

2871-6

Brief description/objective

Apoptosis Stimulating Protein of p53-2, ASPP2, aka 53BP2L, (encoded by TP53BP2) is a pro-apoptotic member of a family of p53 binding proteins. ASPP2 expression is frequently suppressed in human cancers and numerous studies have consistently demonstrated that ASPP2 inhibits cell growth as well as stimulates apoptosis-at least in part through a p53-mediated pathway. Two independent mouse models have shown that ASPP2 is a haplo-insufficient tumor suppressor and underscore the importance of the role of ASPP2 in human cancer. However, mounting evidence suggests that the mechanism(s) of action for ASPP2 are complex and likely extend beyond stimulation of apoptotic programs. Data highlighting this expanding spectrum of potential ASPP2-mediated pathways is summarized along with new results from recent in vivo models suggesting new avenues for investigation.