Evaluation of radiation-related invasion in primary patient-derived glioma cells and validation with established cell lines: impact of different radiation qualities with differing LET.

Publication

Evaluation of radiation-related invasion in primary patient-derived glioma cells and validation with established cell lines: impact of different radiation qualities with differing LET.

Journal Paper/Review - Jun 8, 2018

Wank M, Schilling D, Reindl J, Meyer Benedikt J, Gempt Jens, Motov Stefan, Alexander F, Wilkens J J, Schlegel Jürgen, Schmid T, Combs Stephanie E

Citation

Wank M, Schilling D, Reindl J, Meyer B, Gempt J, Motov S, Alexander F, Wilkens J, Schlegel J, Schmid T, Combs S. Evaluation of radiation-related invasion in primary patient-derived glioma cells and validation with established cell lines: impact of different radiation qualities with differing LET. J Neurooncol 2018; 139:583-590.

Type

Journal Paper/Review (English)

Journal

J Neurooncol 2018; 139

Publication Date

Jun 8, 2018

Issn Electronic

1573-7373

Pages

583-590

Brief description/objective

Glioblastoma multiforme (GBM) is the most common primary brain tumor and has a very poor overall prognosis. Multimodal treatment is still inefficient and one main reason is the invasive nature of GBM cells, enabling the tumor cells to escape from the treatment area causing tumor progression. This experimental study describes the effect of low- and high-LET irradiation on the invasion of primary GBM cells with a validation in established cell systems.