Effect of cyclosporin A in a patient with refractory nephrotic syndrome associated with B chronic lymphocytic leukemia

Publication

Effect of cyclosporin A in a patient with refractory nephrotic syndrome associated with B chronic lymphocytic leukemia

Journal Paper/Review - Jan 1, 1996

Eisterer W, Neyer U, Hilbe W, Diem G, Öhlschlegel Christian, Ludescher C, Thaler J

Units

Pathologie

PubMed

8852499

Citation

Eisterer W, Neyer U, Hilbe W, Diem G, Öhlschlegel C, Ludescher C, Thaler J. Effect of cyclosporin A in a patient with refractory nephrotic syndrome associated with B chronic lymphocytic leukemia. Nephron 1996; 72:468-71.

Type

Journal Paper/Review (English)

Journal

Nephron 1996; 72

Publication Date

Jan 1, 1996

Issn Print

0028-2766

Pages

468-71

Brief description/objective

We report on a patient with an almost 20-year history of B chronic lymphocytic leukemia (B-CLL). During the last 2 years, the patient developed nephrotic syndrome (NS) due to membranous glomerulonephritis (MN), refractory to standard therapeutic regimens. Neither NS nor B-CLL responded objectively to systemic administration of two different combinations of corticosteroids and alkylating agents (chlorambucil, cyclophosphamide). Third-line therapy with cyclosporin A resulted in reduction of proteinuria and improvement of leukemia. Withdrawal of the drug led to an increase in leukocyte count.