Joint Anatomical, Histological, and Imaging Investigation of the Midbrain Target Region for Superolateral Medial Forebrain Bundle Deep Brain Stimulation.

Publication

Joint Anatomical, Histological, and Imaging Investigation of the Midbrain Target Region for Superolateral Medial Forebrain Bundle Deep Brain Stimulation.

Journal Paper/Review - Nov 11, 2024

Coenen Volker Arnd, Zielinski Jana Maxi, Sajonz Bastian Elmar Alexander, Reinacher Peter C, Thierauf-Emberger Annette, Wessolleck Johanna, Frosch Maximilian, Spittau Björn, Schläpfer Thomas Eduard, Baldermann Juan Carlos, Endres Dominique, Lagrèze Wolf Alexander, Döbrössy Máté Daniel, Reisert Marco

Citation

Coenen V, Zielinski J, Sajonz B, Reinacher P, Thierauf-Emberger A, Wessolleck J, Frosch M, Spittau B, Schläpfer T, Baldermann J, Endres D, Lagrèze W, Döbrössy M, Reisert M. Joint Anatomical, Histological, and Imaging Investigation of the Midbrain Target Region for Superolateral Medial Forebrain Bundle Deep Brain Stimulation. Stereotact Funct Neurosurg 2024:1-13.

Type

Journal Paper/Review (English)

Journal

Stereotact Funct Neurosurg 2024

Publication Date

Nov 11, 2024

Issn Electronic

1423-0372

Pages

1-13

Brief description/objective

Deep brain stimulation (DBS) of the superolateral branch of the medial forebrain bundle (slMFB) is currently being researched in clinical trials and open case series as a therapeutic option for treatment-resistant major depressive disorder and treatment-resistant obsessive-compulsive disorder (TR-OCD). There are numerous publications describing stimulation in such proximity to the ventral tegmental area (VTA) and open questions remain concerning the stimulation target and its functional environment. As of right now, we are not aware of any publications that compare the typical electrode placements with the histologically supported tractographic depiction of the target structure.