Protocolised early de-resuscitation in septic shock (REDUCE): protocol for a randomised controlled multicentre feasibility trial.

Publication

Protocolised early de-resuscitation in septic shock (REDUCE): protocol for a randomised controlled multicentre feasibility trial.

Journal Paper/Review - Sep 21, 2023

Messmer Anna, Pietsch Urs, Siegemund Martin, Buehler Philipp K, Waskowski Jan, Müller-Nurasyid Martina, Uehlinger Dominik E, Hollinger Alexa, Filipovic Miodrag, Berger David, Schefold Joerg C, Pfortmueller Carmen A

Citation

Messmer A, Pietsch U, Siegemund M, Buehler P, Waskowski J, Müller-Nurasyid M, Uehlinger D, Hollinger A, Filipovic M, Berger D, Schefold J, Pfortmueller C. Protocolised early de-resuscitation in septic shock (REDUCE): protocol for a randomised controlled multicentre feasibility trial. BMJ Open 2023; 13:e074847.

Type

Journal Paper/Review (English)

Journal

BMJ Open 2023; 13

Publication Date

Sep 21, 2023

Issn Electronic

2044-6055

Pages

e074847

Brief description/objective

Fluid overload is associated with excess mortality in septic shock. Current approaches to reduce fluid overload include restrictive administration of fluid or active removal of accumulated fluid. However, evidence on active fluid removal is scarce. The aim of this study is to assess the efficacy and feasibility of an early de-resuscitation protocol in patients with septic shock.