Azithromycin alters spatial and temporal dynamics of airway microbiota in idiopathic pulmonary fibrosis.

Publication

Azithromycin alters spatial and temporal dynamics of airway microbiota in idiopathic pulmonary fibrosis.

Journal Paper/Review - May 22, 2023

Gijs Pieter-Jan, Daccord Cécile, Bernasconi Eric, Brutsche Martin, Clarenbach Christian F, Hostettler Katrin E, Guler Sabina A, Mercier Louis, Ubags Niki, Funke-Chambour Manuela, von Garnier Christophe

Citation

Gijs P, Daccord C, Bernasconi E, Brutsche M, Clarenbach C, Hostettler K, Guler S, Mercier L, Ubags N, Funke-Chambour M, von Garnier C. Azithromycin alters spatial and temporal dynamics of airway microbiota in idiopathic pulmonary fibrosis. ERJ Open Res 2023; 9

Type

Journal Paper/Review (English)

Journal

ERJ Open Res 2023; 9

Publication Date

May 22, 2023

Issn Print

2312-0541

Brief description/objective

High bacterial burden in the lung microbiota predicts progression of idiopathic pulmonary fibrosis (IPF). Azithromycin (AZT) is a macrolide antibiotic known to alter the lung microbiota in several chronic pulmonary diseases, and observational studies have shown a positive effect of AZT on mortality and hospitalisation rate in IPF. However, the effect of AZT on the lung microbiota in IPF remains unknown.