Publication
Intractable ascites associated with mycophenolate in a simultaneous kidney-pancreas transplant patient: a case report.
Journal Paper/Review - Dec 12, 2017
Weber Nina T, Sigaroudi Ali, Ritter Alexander, Boss Andreas, Lehmann Kuno, Goodman David, Farese Stefan, Weiler Stefan, Müller Thomas F
Units
PubMed
Doi
Contact
Citation
Type
Journal
Publication Date
Issn Electronic
Pages
Brief description/objective
Mycophenolic acid (MPA), either given as an ester pro-drug or as an enteric-coated sodium salt, is the most commonly prescribed anti-proliferative immunosuppressive agent used following organ transplantation and widely applied in immune-mediated diseases. Clinicians are well aware of common adverse reactions related to MPA treatment, in particular diarrhea, leukopenia and infections. Here we report a case of severe, persistent ascites associated with MPA treatment. The otherwise unexplained and intractable ascites, requiring repeated paracenteses for more than 8 months, rapidly ceased with stopping the MPA treatment. To our knowledge this is the first case of severe ascites associated with MPA treatment reported in the scientific literature.