Publication

Statistical analysis plan for the randomized controlled trial Tenecteplase in Wake-up Ischaemic Stroke Trial (TWIST).

Journal Paper/Review - May 19, 2022

Units
PubMed
Doi
Contact

Citation
Eltoft A, Wilsgaard T, Roaldsen M, Søyland M, Lundström E, Petersson J, Indredavik B, Putaala J, Christensen H, Kõrv J, Jatužis D, Engelter S, De Marchis G, Werring D, Robinson T, Tveiten A, Mathiesen E. Statistical analysis plan for the randomized controlled trial Tenecteplase in Wake-up Ischaemic Stroke Trial (TWIST). Trials 2022; 23:421.
Type
Journal Paper/Review (English)
Journal
Trials 2022; 23
Publication Date
May 19, 2022
Issn Electronic
1745-6215
Pages
421
Brief description/objective

Patients with wake-up ischemic stroke are frequently excluded from thrombolytic treatment due to unknown symptom onset time and limited availability of advanced imaging modalities. The Tenecteplase in Wake-up Ischaemic Stroke Trial (TWIST) is a randomized controlled trial of intravenous tenecteplase 0.25 mg/kg and standard care versus standard care alone (no thrombolysis) in patients who wake up with acute ischemic stroke and can be treated within 4.5 h of wakening based on non-contrast CT findings.