AXL expression on homeostatic resident liver macrophages is reduced in cirrhosis following GAS6 production by hepatic stellate cells.

Publication

AXL expression on homeostatic resident liver macrophages is reduced in cirrhosis following GAS6 production by hepatic stellate cells.

Journal Paper/Review - Mar 31, 2023

Pop Oltin-Tiberiu, Geng Anne, Flint Emilio, Singanayagam Arjuna, Ercan Caner, Possamai Lucia A, Patel Vishal C, Künzler-Heule Patrizia, Meier Marie-Anne, Soysal Savas D, Hruz Petr, Kollmar Otto, Tatham Kate C, Ward Josie K, Mullhaupt Beat, Weber Achim, Wendon Julia, Niess Jan Hendrik, Heim Markus, Semela David, Weston Christopher J, Antoniades Charalambos G, Terracciano Luigi, Triantafyllou Evangelos, Brenig Robert, Bernsmeier Christine

Citation

Pop O, Geng A, Flint E, Singanayagam A, Ercan C, Possamai L, Patel V, Künzler-Heule P, Meier M, Soysal S, Hruz P, Kollmar O, Tatham K, Ward J, Mullhaupt B, Weber A, Wendon J, Niess J, Heim M, Semela D, Weston C, Antoniades C, Terracciano L, Triantafyllou E, Brenig R, Bernsmeier C. AXL expression on homeostatic resident liver macrophages is reduced in cirrhosis following GAS6 production by hepatic stellate cells. Cell Mol Gastroenterol Hepatol 2023

Type

Journal Paper/Review (English)

Journal

Cell Mol Gastroenterol Hepatol 2023

Publication Date

Mar 31, 2023

Issn Electronic

2352-345X

Brief description/objective

AXL and MERTK expression on circulating monocytes modulated immune responses in patients with cirrhosis (CD14HLA-DRAXL) and acute-on-chronic liver failure (CD14MERTK). AXL expression involved enhanced efferocytosis, sustained phagocytosis, but reduced TNF-α/IL-6 production and T cell activation, suggesting a homeostatic function. Axl was expressed on murine airway in tissues contacting the external environment- but not interstitial lung-, and tissue-resident synovial lining macrophages. We assessed AXL expression on tissue macrophages in patients with cirrhosis.