Publication

Duration between aneurysm rupture and treatment and its association with outcome in aneurysmal subarachnoid haemorrhage.

Journal Paper/Review - Jan 27, 2023

Units
PubMed
Doi
Contact

Citation
Hostettler I, Lange N, Schwendinger N, Frangoulis S, Hirle T, Trost D, Gempt J, Kreiser K, Wostrack M, Meyer B. Duration between aneurysm rupture and treatment and its association with outcome in aneurysmal subarachnoid haemorrhage. Sci Rep 2023; 13:1527.
Type
Journal Paper/Review (English)
Journal
Sci Rep 2023; 13
Publication Date
Jan 27, 2023
Issn Electronic
2045-2322
Pages
1527
Brief description/objective

Timely treatment of aneurysmal subarachnoid haemorrhage (aSAH) is key to prevent further rupture and poor outcome. We evaluated complications and outcome adjusting for time from haemorrhage to treatment. Retrospective analysis of aSAH patients admitted between 2006 and 2020. Data was collected using standardized case report forms. We compared risk factors using multivariable logistic regression. We included 853 patients, 698 (81.8%) were treated within 24 h. Patients with higher Hunt and Hess grades were admitted and treated significantly faster than those with lower grades (overall p-value < 0.001). Fifteen patients (1.8%) rebled before intervention. In the multivariable logistic analysis adjusting for timing, Barrow Neurological Institute score and intracerebral haemorrhage were significantly associated with rebleeding (overall p-value 0.006; OR 3.12, 95%CI 1.09-8.92, p = 0.03, respectively) but timing was not. Treatment > 24 h was associated with higher mortality and cerebral infarction in only the subgroup of lower grades aSAH (OR 3.13, 1.02-9.58 95%CI, p-value = 0.05; OR 7.69, 2.44-25.00, p-value < 0.001, respectively). Therefore treatment > 24 h after rupture is associated with higher mortality and cerebral infarction rates in lower grades aSAH. Delay in treatment primarily affects lower grade aSAH patients. Patients with lower grade aSAH ought to be treated with the same urgency as higher-grade aSAH.