Sex-specific evaluation and redevelopment of the GRACE score in non-ST-segment elevation acute coronary syndromes in populations from the UK and Switzerland: a multinational analysis with external cohort validation.

Publication

Sex-specific evaluation and redevelopment of the GRACE score in non-ST-segment elevation acute coronary syndromes in populations from the UK and Switzerland: a multinational analysis with external cohort validation.

Journal Paper/Review - Aug 29, 2022

Wenzl Florian A, Kraler Simon, Ambler Gareth, Weston Clive, Herzog Sereina A, Räber Lorenz, Muller Olivier, Camici Giovanni G, Roffi Marco, Rickli Hans, Fox Keith A A, de Belder Mark, Radovanovic Dragana, Deanfield John, Lüscher Thomas F

Citation

Wenzl F, Kraler S, Ambler G, Weston C, Herzog S, Räber L, Muller O, Camici G, Roffi M, Rickli H, Fox K, de Belder M, Radovanovic D, Deanfield J, Lüscher T. Sex-specific evaluation and redevelopment of the GRACE score in non-ST-segment elevation acute coronary syndromes in populations from the UK and Switzerland: a multinational analysis with external cohort validation. Lancet 2022; 400:744-756.

Type

Journal Paper/Review (English)

Journal

Lancet 2022; 400

Publication Date

Aug 29, 2022

Issn Electronic

1474-547X

Pages

744-756

Brief description/objective

The Global Registry of Acute Coronary Events (GRACE) 2.0 score was developed and validated in predominantly male patient populations. We aimed to assess its sex-specific performance in non-ST-segment elevation acute coronary syndromes (NSTE-ACS) and to develop an improved score (GRACE 3.0) that accounts for sex differences in disease characteristics.