Interleukin-6 Is an Early Plasma Marker of Severe Postoperative Complications in Thoracic Surgery: Exploratory Results From a Substudy of a Randomized Controlled Multicenter Trial.

Publication

Interleukin-6 Is an Early Plasma Marker of Severe Postoperative Complications in Thoracic Surgery: Exploratory Results From a Substudy of a Randomized Controlled Multicenter Trial.

Journal Paper/Review - Jan 1, 2022

Neff Thomas A, Braun Julia, Rana Dhanu, Puhan Milo, Filipovic Miodrag, Seeberger Manfred, Stuber Frank, Neff Simona B, Beck-Schimmer Beatrice, Schläpfer Martin

Citation

Neff T, Braun J, Rana D, Puhan M, Filipovic M, Seeberger M, Stuber F, Neff S, Beck-Schimmer B, Schläpfer M. Interleukin-6 Is an Early Plasma Marker of Severe Postoperative Complications in Thoracic Surgery: Exploratory Results From a Substudy of a Randomized Controlled Multicenter Trial. Anesth Analg 2022; 134:123-132.

Type

Journal Paper/Review (English)

Journal

Anesth Analg 2022; 134

Publication Date

Jan 1, 2022

Issn Electronic

1526-7598

Pages

123-132

Brief description/objective

Postoperative complications in surgery are a significant burden, not only for the patients but also economically. While several predicting factors have already been identified, it is still not well known if increased levels of inflammatory markers in the immediate perioperative phase correlate with a higher incidence of postoperative complications. This study aimed to evaluate which patient characteristics and intraoperative parameters correlate with increased plasma values of monocyte chemoattractant protein 1 (MCP-1) and interleukin 6 (IL-6) of thoracic surgery patients. A second goal was to explore whether MCP-1 and IL-6 are associated with the incidence of postoperative complications. We hypothesized that there is a positive association between inflammatory markers and the occurrence of complications within 6 months after surgery.