Low secondary attack rate after prolonged exposure to sputum smear positive miliary tuberculosis in a neonatal unit.
Journal Paper/Review - Dec 5, 2022
Popovici Roxana M, Kaelin Marisa B, Kuster Stefan P, Sax Hugo, Rampini Silvana K, Zbinden Reinhard, Relly Christa, Zacek Bea, Bassler Dirk, Fontijn Jehudith R, Berger Christoph T
Several neonatal intensive care units (NICU) have reported exposure to sputum smear positive tuberculosis (TB). NICE guidelines give support regarding investigation and treatment intervention, but not for contact definitions. Data regarding the reliability of any interferon gamma release assay (IGRA) in infants as a screening test for TB infection is scarce. We report an investigation and management strategy and evaluated the viability of IGRA (T-Spot) in infants and its concordance to the tuberculin skin test (TST).