EndoVAscular treatment and ThRombolysis for Ischemic Stroke Patients (EVA-TRISP) registry: basis and methodology of a pan-European prospective ischaemic stroke revascularisation treatment registry

Publication

EndoVAscular treatment and ThRombolysis for Ischemic Stroke Patients (EVA-TRISP) registry: basis and methodology of a pan-European prospective ischaemic stroke revascularisation treatment registry

Journal Paper/Review - Aug 9, 2021

EVA-TRISP Investigators, Magoni Mauro, Gralla Jan, Papanagiotou Panagiotis, Kastrup Andreas, Psychogios Marios, Liman Jan, Brehm Alex, Gomori John, Cohen Jose E, Leker Ronen R, Lappalainen Kimmo, Rentzos Alexandros, Kägi Georg, Majoie Charles B L M, Bohner Georg, Vukasinovic Ivan, Tatlisumak Turgut, Strbian Daniel, Engelter Stefan, Nederkoorn Paul J J, Nolte Christian H, Jood Katarina, Kapsalaki Eftychia, Ntaios George, Möhlenbruch Markus, Bendszus Martin, Kulcsar Zsolt, Weber Johannes, Cvetic Vladimir, Feil Katharina, Kellert Lars, Bricout Nicolas, Scheitz Jan F, Baharoglu Merih I, Traenka Christopher, Lyrer Philippe, Sibolt Gerli, Martinez-Majander Nicolas, Karlsson Jan-Erik, Karlsson Camilla, Erdur Hebun, Zinkstok Sanne M, Gensicke Henrik, Curtze Sami, Hénon Hilde, Leys Didier, Eskandari Ashraf, Wegener Susanne, Luft Andreas, Jovanovic Dejana R, Padjen Visnja, Zini Andrea, Pezzini Alessandro, Seiffge David J, Sarikaya Hakan, Fischer Urs, Arnold Marcel, Ringleb Peter Arthur, Hametner Christian, Michel Patrik, Nordanstig Annika

Citation

EVA-TRISP Investigators, Magoni M, Gralla J, Papanagiotou P, Kastrup A, Psychogios M, Liman J, Brehm A, Gomori J, Cohen J, Leker R, Lappalainen K, Rentzos A, Kägi G, Majoie C, Bohner G, Vukasinovic I, Tatlisumak T, Strbian D, Engelter S, Nederkoorn P, Nolte C, Jood K, Kapsalaki E, Ntaios G, Möhlenbruch M, Bendszus M, Kulcsar Z, Weber J, Cvetic V, Feil K, Kellert L, Bricout N, Scheitz J, Baharoglu M, Traenka C, Lyrer P, Sibolt G, Martinez-Majander N, Karlsson J, Karlsson C, Erdur H, Zinkstok S, Gensicke H, Curtze S, Hénon H, Leys D, Eskandari A, Wegener S, Luft A, Jovanovic D, Padjen V, Zini A, Pezzini A, Seiffge D, Sarikaya H, Fischer U, Arnold M, Ringleb P, Hametner C, Michel P, Nordanstig A. EndoVAscular treatment and ThRombolysis for Ischemic Stroke Patients (EVA-TRISP) registry: basis and methodology of a pan-European prospective ischaemic stroke revascularisation treatment registry. BMJ Open 2021; 11:e042211.

Type

Journal Paper/Review (English)

Journal

BMJ Open 2021; 11

Publication Date

Aug 9, 2021

Issn Electronic

2044-6055

Pages

e042211

Brief description/objective

PURPOSE
The Thrombolysis in Ischemic Stroke Patients (TRISP) collaboration was a concerted effort initiated in 2010 with the purpose to address relevant research questions about the effectiveness and safety of intravenous thrombolysis (IVT). The collaboration also aims to prospectively collect data on patients undergoing endovascular treatment (EVT) and hence the name of the collaboration was changed from TRISP to EVA-TRISP. The methodology of the former TRISP registry for patients treated with IVT has already been published. This paper focuses on describing the EVT part of the registry.

PARTICIPANTS
All centres committed to collecting predefined variables on consecutive patients prospectively. We aim for accuracy and completeness of the data and to adapt local databases to investigate novel research questions. Herein, we introduce the methodology of a recently constructed academic investigator-initiated open collaboration EVT registry built as an extension of an existing IVT registry in patients with acute ischaemic stroke (AIS).

FINDINGS TO DATE
Currently, the EVA-TRISP network includes 20 stroke centres with considerable expertise in EVT and maintenance of high-quality hospital-based registries. Following several successful randomised controlled trials (RCTs), many important clinical questions remain unanswered in the (EVT) field and some of them will unlikely be investigated in future RCTs. Prospective registries with high-quality data on EVT-treated patients may help answering some of these unanswered issues, especially on safety and efficacy of EVT in specific patient subgroups.

FUTURE PLANS
This collaborative effort aims at addressing clinically important questions on safety and efficacy of EVT in conditions not covered by RCTs. The TRISP registry generated substantial novel data supporting stroke physicians in their daily decision making considering IVT candidate patients. While providing observational data on EVT in daily clinical practice, our future findings may likewise be hypothesis generating for future research as well as for quality improvement (on EVT). The collaboration welcomes participation of further centres willing to fulfill the commitment and the outlined requirements.