Granulomatous Pneumocystis carinii pneumonia in Wegener's granulomatosis

Publication

Granulomatous Pneumocystis carinii pneumonia in Wegener's granulomatosis

Journal Paper/Review - Jan 1, 2000

Ullmer E, Mayr M, Binet Françoise-Isabelle, Ebnöther-Staub C, Dalquen P, Solèr M, Tamm M

Units

Nephrologie | Transplantationsmedizin

PubMed

10678649

Citation

Ullmer E, Mayr M, Binet F, Ebnöther-Staub C, Dalquen P, Solèr M, Tamm M. Granulomatous Pneumocystis carinii pneumonia in Wegener's granulomatosis. The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2000; 15:213-6.

Type

Journal Paper/Review (English)

Journal

The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2000; 15

Publication Date

Jan 1, 2000

Issn Print

0903-1936

Pages

213-6

Brief description/objective

This study reports on a first case of granulomatous Pneumocystis carinii pneumonia (PCP) in a human immunodeficiency virus-negative patient with antineutrophil cytoplasmic antibody-positive Wegener's granulomatosis whilst receiving immunosuppressive treatment. The patient presented with diffuse alveolar haemorrhage, pauci-immune rapid progressive glomerulonephritis and leukocytoclastic vasculitis of the skin. Granulomatous Pneumocystis carinii pneumonia developed under immunosuppressive treatment with cyclophosphamide and prednisone. At the time Pneumocystis carinii pneumonia developed, there was a marked lymphopenia with a very low CD8+ cell count in the blood. Grocott staining in bronchoalveolar lavage fluid revealed no Pneumocystis carinii. The diagnosis was made via a video-assisted thoracoscopic lung biopsy which showed granulomas containing high numbers of Pneumocystis carinii cysts.