Increase in bone mineral density after successful parathyroidectomy for tertiary hyperparathyroidism after renal transplantation

Publication

Increase in bone mineral density after successful parathyroidectomy for tertiary hyperparathyroidism after renal transplantation

Journal Paper/Review - Aug 1, 2008

Collaud Stéphane, Robert John H, Martin Pierre-Yves, Rizzoli René, Myers Patrick O, Binet Françoise-Isabelle, Marangon Nicola, Clerici Thomas, Trombetti Andrea, Staub-Zähner Tania, Triponez Frederic

Citation

Collaud S, Robert J, Martin P, Rizzoli R, Myers P, Binet F, Marangon N, Clerici T, Trombetti A, Staub-Zähner T, Triponez F. Increase in bone mineral density after successful parathyroidectomy for tertiary hyperparathyroidism after renal transplantation. World journal of surgery 2008; 32:1795-801.

Type

Journal Paper/Review (English)

Journal

World journal of surgery 2008; 32

Publication Date

Aug 1, 2008

Issn Print

0364-2313

Pages

1795-801

Brief description/objective

BACKGROUND: Few studies have reported changes of bone mineral density (BMD) after parathyroidectomy in patients with persistent hyperparathyroidism after renal transplantation (3 HPT). PATIENTS AND METHODS: We retrospectively analyzed 14 patients who underwent successful parathyroidectomy for 3 HPT and who had available BMD data before and after parathyroidectomy. RESULTS: Median follow-up time was 26 months (IQR: 16.8-40.2). Serum calcium levels decreased significantly after parathyroidectomy (2.32 +/- 0.09 versus 2.66 +/- 0.16 mmol/l; p < 0.01), as did PTH levels (5.1 +/- 3.0 versus 27.8 +/- 23.7 pmol/l; p < 0.01). Nine patients (64%) had a steroid-free immunosuppression at follow-up. Mean increase in BMD was 9.5 +/- 8.0% for the spine and 9.5 +/- 7.9% for the hip (p < 0.01 for both sites). Patients with osteoporosis (T-score