Aspirin versus anticoagulation in cervical artery dissection (TREAT-CAD): an open-label, randomised, non-inferiority trial.

Publication

Aspirin versus anticoagulation in cervical artery dissection (TREAT-CAD): an open-label, randomised, non-inferiority trial.

Journal Paper/Review - Mar 23, 2021

Engelter Stefan T, Traenka Christopher, Gensicke Henrik, Schaedelin Sabine A, Luft Andreas R, Simonetti Barbara Goeggel, Fischer Urs, Michel Patrik, Sirimarco Gaia, Kägi Georg, Vehoff Jochen, Nedeltchev Krassen, Kahles Timo, Kellert Lars, Rosenbaum Sverre, von Rennenberg Regina, Sztajzel Roman F, Leib Stephen L, Jung Simon, Gralla Jan, Bruni Nicole, Seiffge David Julian, Feil Katharina, Polymeris Alexandros A, Steiner Levke, Hamann Janne, Bonati Leo H, Brehm Alex, De Marchis Gian Marco, Peters Nils, Stippich Christoph, Nolte Christian H, Christensen Hanne, Wegener Susanne, Psychogios Marios-Nikos, Arnold Marcel, Lyrer Philippe A, TREAT-CAD investigators

Citation

Engelter S, Traenka C, Gensicke H, Schaedelin S, Luft A, Simonetti B, Fischer U, Michel P, Sirimarco G, Kägi G, Vehoff J, Nedeltchev K, Kahles T, Kellert L, Rosenbaum S, von Rennenberg R, Sztajzel R, Leib S, Jung S, Gralla J, Bruni N, Seiffge D, Feil K, Polymeris A, Steiner L, Hamann J, Bonati L, Brehm A, De Marchis G, Peters N, Stippich C, Nolte C, Christensen H, Wegener S, Psychogios M, Arnold M, Lyrer P, TREAT-CAD investigators. Aspirin versus anticoagulation in cervical artery dissection (TREAT-CAD): an open-label, randomised, non-inferiority trial. Lancet Neurol 2021; 20:341-350.

Type

Journal Paper/Review (English)

Journal

Lancet Neurol 2021; 20

Publication Date

Mar 23, 2021

Issn Electronic

1474-4465

Pages

341-350

Brief description/objective

Cervical artery dissection is a major cause of stroke in young people (aged <50 years). Historically, clinicians have preferred using oral anticoagulation with vitamin K antagonists for patients with cervical artery dissection, although some current guidelines-based on available evidence from mostly observational studies-suggest using aspirin. If proven to be non-inferior to vitamin K antagonists, aspirin might be preferable, due to its ease of use and lower cost. We aimed to test the non-inferiority of aspirin to vitamin K antagonists in patients with cervical artery dissection.