Elevated HbA1c is not associated with recurrent venous thromboembolism in the elderly, but with all-cause mortality- the SWEETCO 65+ study

Publication

Elevated HbA1c is not associated with recurrent venous thromboembolism in the elderly, but with all-cause mortality- the SWEETCO 65+ study

Journal Paper/Review - Feb 12, 2020

Mathis Alexandra, Staub Daniel, Aschwanden Markus, Frauchiger Beat, Osterwalder Joseph, Kucher Nils, Matter Christian M, Banyai Martin, Hugli Oliver, Righini Marc, Angelillo-Scherrer Anna, Rodondi Nicolas, Villiger Lukas, Reiner Martin F, Egloff Michael, Schmid Hans Ruedi, Stivala Simona, Limacher Andreas, Méan Marie, Aujesky Drahomir, Beer Juerg H

Citation

Mathis A, Staub D, Aschwanden M, Frauchiger B, Osterwalder J, Kucher N, Matter C, Banyai M, Hugli O, Righini M, Angelillo-Scherrer A, Rodondi N, Villiger L, Reiner M, Egloff M, Schmid H, Stivala S, Limacher A, Méan M, Aujesky D, Beer J. Elevated HbA1c is not associated with recurrent venous thromboembolism in the elderly, but with all-cause mortality- the SWEETCO 65+ study. Sci Rep 2020; 10:2495.

Type

Journal Paper/Review (English)

Journal

Sci Rep 2020; 10

Publication Date

Feb 12, 2020

Issn Electronic

2045-2322

Pages

2495

Brief description/objective

The association of glycated hemoglobin (HbA1c) with venous thromboembolism (VTE) and death in the elderly is unknown. In the SWEETCO 65+ study we analyzed prospectively a Swiss Cohort of Elderly Patients with Venous Thromboembolism (SWITCO 65+). 888 patients were enrolled for the SWEETCO 65+ analysis. HbA1c was determined at baseline and divided into three categories (HbA1c < 5.7%, normal range; 5.7-6.49%, pre-diabetic range; and >6.5%, diabetic range). Median follow-up was 2.5 years. The primary endpoint was recurrent VTE. Secondary endpoints included all-cause mortality and major bleeds. The total prevalence of diabetes was 22.1%. The risk of recurrent VTE was similar in patients with HbA1c with pre-diabetes (adjusted subhazard ratio (aSHR) 1.07 [0.70 to 1.63]) and diabetes (aSHR 0.73 [0.39 to 1.37]) as compared to those with a HbA1c in the normal range. However, a HbA1c ≥ 6.5% (median IQ range 7.0 [6.70;7.60]) was significantly associated with a higher risk of all-cause mortality (adjusted hazard ratio [aHR] 1.83 [1.21 to 2.75]). In summary we found no association between HbA1c and major bleeding. Elevated HbA1c levels are not associated with recurrent VTE but with increased all-cause mortality in an elderly population with acute VTE.