Fat Grafts Show Higher Hypoxia, Angiogenesis, Adipocyte Proliferation, and Macrophage Infiltration than Flaps in a Pilot Mouse Study.

Publication

Fat Grafts Show Higher Hypoxia, Angiogenesis, Adipocyte Proliferation, and Macrophage Infiltration than Flaps in a Pilot Mouse Study.

Journal Paper/Review - Jan 3, 2023

Thomas Benjamin, Warszawski Jan, Falkner Florian, Bleichert Sonja, Haug Valentin, Bigdeli Amir Khosrow, Schulte Matthias, Hoffmann Sabrina Hl, Garvalov Boyan K, Schreiber Caroline, Takamiya Masanari, Sleeman Jonathan P, Schmidt Volker, Kneser Ulrich, Pichler Bernd, Dimmler Arno, Thiele Wilko

Citation

Thomas B, Warszawski J, Falkner F, Bleichert S, Haug V, Bigdeli A, Schulte M, Hoffmann S, Garvalov B, Schreiber C, Takamiya M, Sleeman J, Schmidt V, Kneser U, Pichler B, Dimmler A, Thiele W. Fat Grafts Show Higher Hypoxia, Angiogenesis, Adipocyte Proliferation, and Macrophage Infiltration than Flaps in a Pilot Mouse Study. Plast Reconstr Surg 2023; 152:96e-109e.

Type

Journal Paper/Review (English)

Journal

Plast Reconstr Surg 2023; 152

Publication Date

Jan 3, 2023

Issn Electronic

1529-4242

Pages

96e-109e

Brief description/objective

Over 137,000 breast reconstructions are performed annually by American Society of Plastic Surgeons (ASPS) members. Vascularized flaps and avascular lipofilling each account for over 33,000 autologous reconstructions. Although clinical and experimental observations suggest biologic differences with diverging effects on locoregional tumor control, comparative animal models are lacking. The authors standardized existing techniques in immunocompetent mice, laying the foundation for in vivo models of autologous breast reconstruction combinable with orthotopic tumor implantations.