Correlation of age and the diameter of the cervical nerve roots C5 and C6 during the first two years of life analysed by high-resolution ultrasound imaging
Jacoba van der Linde1 Carole Jenny1 Thomas Hundsberger2 Philip J. Broser1,3
Journal Paper/Review - May 12, 2022
Aim: To analyze the increase in diameter of the nerve roots C5 and C6 in early
Methods: The nerve roots of 56 children aged 0 days to 10 years (47 younger than
2 years) were examined by high-resolution ultrasound imaging. The correlation of
diameter and age was statistically tested and a logarithmic regression analysis was
performed to develop a logarithmic growth model.
Results: The increase in nerve root diameter is greatest during the first 2 years of
life and then the growth rate decreases steadily. The relationship between age and
diameter follows a logarithmic curve (p < 10–8).
Interpretation: The main increase in the diameter of the nerve roots happens in the
first 2 years of life. Comparing data from a previous study, our data also suggest that the
maturation of the proximal part of the median nerve is comparable to the maturation
of its distal segments. This suggests a synchronous maturation of the axons andmyelin
sheath for the whole extent of the nerve, from the radix to its very distal part.
What This Paper Adds: Normative values for the size of the cervical nerve roots C5
and C6; an insight into the maturation of the proximal parts of the peripheral nervous
system; and the correlation between age and cervical root diameter.