Projects
Search from 1147 projects:
1147 Project(s)
Offene, nicht kontrollierte, multizentrische Phase IIIb Studie zur Beurteilung von Riociguat (BAY 63-2521) bei Patienten mit Chronisch Thromboembolischer Pulmonaler Hypertonie (CTEPH)
Jun 1, 2013Objective 1) To assess safety and tolerability, clinical effects of riociguat. 2) To provide access to riociguat for patients with in-operable chronic thromboembolic pulmonary hypertension (CTEPH), or recurrent or persisting pulmonary hypertension (P...
Clinical Studies - Jun 1, 2013 - Jun 1, 2015
Aborted
Project leader: Brutsche Martin
Members: Pellet Sarah, Finger Rebekka
Wertigkeit der PET/CT mit Sonographie und Feinnadelpunktion zum Nachweis einer cervikalen Lymphknotenpersistenz nach primärer Radiochemotherapie eines Plattenepithelkarzinomes der Mundhöhle, des Pharynx und des Larynx
Jun 1, 2013
Clinical Studies - Jun 1, 2013 - Jun 1, 2014
Automatically Closed
Project leader: Broglie Däppen Martina
Members: Stöckli Sandro
Clinical evaluation of a polyvalent vaccine against Salmonella enterica in a phase I/II Study
Jun 1, 2013Salmonella enterica infections are an important global health problem with more than 20 million individuals suffering from enteric fever annually and more than 200’000 lethal cases per year. Although enteric fever can be treated appropriately with an...
Fundamental Research - Jun 1, 2013 - Dec 31, 2016
Automatically Closed
Project leader: Ludewig Burkhard, Vernazza Pietro
Members: Carreño Juan-Manuel
Sekretion von Katecholaminen und ihrer methoxylierten Metabolite durch die menschliche Nebenniere und durch Phäochromozytome
May 30, 2013Im Rahmen einer klinischen Studie wird der Katecholamin- und Metanephrinmetabolismus in Primärzellkulturen von Phäochromozytomen untersucht und mit klinischen und biochemischen Parametern der operierten Patienten zu verglichen.
Clinical Studies - May 30, 2013 - Dec 31, 2020
Automatically Closed
Project leader: Brändle Michael
Members: Bilz Stefan, Krull Ina
BIOHELIX II : The treatment of coronary artery lesions using the PRO-Kinetic Energy Cobalt-Chromium, Bare-Metal Stent
May 24, 2013Die Behandlung von koronaren Läsionen mit PRO-Kinetic Energy Kobalt-Chrom Metall Stent (BIOHELIX II) Das primäre Ziel dieser Studie ist der Nachweis der klinischen Leistungsfähigkeit des PRO-Kinetic Energy Stents bei Patienten mit Atherosklerose in...
Clinical Studies - May 24, 2013 - May 24, 2017
Aborted
Project leader: Rickli Hans
Members: Schneider Irene
A randomized phase II trial of pertuzumab in combination with trastuzumab with or without chemotherapy, both followed by T-DM1 in case of progression, in patients with HER2-positive metastatic breast cancer
May 1, 2013The primary objective of this trial is to evaluate the efficacy in terms of overall survival (OS) at 24 months of a chemotherapy-free dual HER2-inbibition with trastuzumab and pertuzumab (first-line) followed by T-DM1 (second-line) and of a chemother...
Clinical Studies - May 1, 2013 - May 1, 2019
Automatically Closed
Project leader: Weder Patrik
Members: Thürlimann Beat, Ruhstaller Thomas, Maier Reinhard, Riniker Salome, Öhlschlegel Christian, Hasler-Strub Ursula
Swiss-Romanian Cooperation Programme: Overcoming disparities on access to quality basic palliative care in the community: Partnerships to identify and improve clinical, educational, legal and economical barriers
May 1, 2013The project is based on a Swiss-Romanian partnership to develop palliative care in Romania, based on a systematic analysis of the needs, with Swiss experts input in drafting and answering major challenges in offering care to cancer patients. The burd...
Clinical Studies - May 1, 2013 - Apr 30, 2016
Automatically Closed
Project leader: Strasser Florian
Members: Behnke Nadine, Magayakalbermatten N
SAKK 22/10: A randomized phase II trial of pertuzumab in combination with trastuzumab with or without chemothera-py, both followed by T-DM1 in case of progression, in pa-tients with HER2-positive metastatic breast cancer
Apr 29, 2013In der vorliegenden Studie wird eine neue Strategie für die Behandlung des HER2-positiven metastasierenden Brustkrebses untersucht, bei der die Erstlinientherapie aus Herceptin® und Perjeta® besteht und somit chemotherapiefrei ist. Bei Fortschreiten...
Clinical Studies - Apr 29, 2013 - Jun 27, 2015
Automatically Closed
Project leader: Weder Patrik
Members: Ruhstaller Thomas, Hasler-Strub Ursula, Maier Reinhard, Öhlschlegel Christian, Riniker Salome, Kaelin Martin, Hochstrasser Andreas, Thürlimann Beat
AMG 145 20110115 LAPLACE
Apr 1, 2013A Double-blind, Randomized, Placebo and Ezetimibe Controlled, Multicenter Study to Evaluate Safety, Tolerability and Efficacy of AMG 145 on LDL-C in Combination With Statin Therapy in Subjects With Primary Hypercholesterolemia and Mixed Dyslipidemia;
Clinical Studies - Apr 1, 2013 - Mar 3, 2014
Completed
Project leader: Rickli Hans
Members: Schefer Mirjam, Vollenbroich Rene
Selection and education of heart-specific Th cells by thymic and lymph node stromal cells
Apr 1, 2013Myocarditis is a frequent disease in children and young adults that can precipitate lethal dilated cardiomyopathy (DCM). Since some heart antigens, such as the cardiac myosin heavy chain alpha (myhca) are not represented in the thymus, heart-specific...
Fundamental Research - Apr 1, 2013 - Mar 31, 2016
Completed
Project leader: Ludewig Burkhard
Members: Pérez Shibayama Christian Ivan, Bösch Maximilian, Gil Cruz Cristina
GeDDiS: A prospective randomised controlled phase III trial of gemcitabine and docetaxel com-pared with doxorubicin as first line treatment in previously untreated advanced unresectable or metastatic soft tissue sarcomas
Mar 31, 2013Weichteilsarkome sind seltene Tumoren, weshalb bei der Durchführung klinischer Studien Kollaborationen eingegangen werden müssen. Die Teilnahme an einer internationalen, multizentrischen, Phase III Studie bei einer Tumorentität mit Orphan Disease Sta...
Clinical Studies - Mar 31, 2013 - Dec 23, 2013
Completed
Project leader: Rothermundt Christian
Members: Cerny Thomas
COBRA PzF Coronary Stent System in Native Coronary Arteries for Early Healing, Thrombus Inhibition, Endothelialization, and Avoiding Long-Term Dual Anti-Platelet Therapy – The PzF SHIELD Trial
Mar 22, 2013The main objective of this study is to evaluate the safety and effectiveness of the COBRA PzF Coronary Stent System in the treatment of de novo lesions in native coronary arteries. The COBRA PzF Coronary Stent System is a balloon-expandable bare met...
Clinical Studies - Mar 22, 2013 - Mar 31, 2021
Completed
Project leader: Weilenmann Daniel
Members: Schneider Irene, Schefer Mirjam
Eine Untersuchung der Pathogenese des Terson Syndroms und der Rolle der Liquorproteine Gesamt-Tau / Amyloid-ß 40 und 42 bei der aneurysmatischen Subarachnoidalblutung
Mar 15, 2013Die intra-vitreale Blutung in Assoziation mit einer aneurysmatischen Subarachnoidalblutung (aSAB) ist ein häufiger Befund und wurde zuerst vom Deutschen Ophthalmologen Moritz Litten im Jahr 1881 beschrieben. Der französische Ophthalmologe Albert Ters...
Clinical Studies - Mar 15, 2013 - Mar 31, 2015
Completed
Project leader: Stienen Martin N.
Members: Joswig Holger, Fournier Jean-Yves, Valmaggia Christophe, Sédille-Mostafaie Nazanin, Korte Wolfgang, Haile Sarah
In vitro proteotoxic synergism of nelfinavir and carfilzomib in solid cancer cell lines
Mar 1, 2013HER2-positive breast cancer accounts for approximately 25-30% of all breast cancer cases, and carries a bad prognosis compared to HER2-negative breast cancer. Despite recent advances with the development of HER2-targeted treatments, mainly trastuzuma...
Fundamental Research - Mar 1, 2013 - Dec 31, 2014
Automatically Closed
Members: Driessen Christoph
Prognostic value of serial measurements of the optic nerve sheet diameter by ultrasaound in comatous patients after successful resuscitation
Feb 13, 2013Bei Patienten nach erfolgreicher Reanimation ist die neurologische Prognose schwierig beurteilbar. Insbesondere sind während den ersten 72 h nur ungenügende prognostische Schätzungen möglich. Die Sonographie des N. opticus ist einfach durchzuführen u...
Clinical Studies - Feb 13, 2013 - Feb 13, 2013
Automatically Closed
Kommunikation über Sterben und Tod aus der soziologischen Perspektive
Feb 1, 2013Hintergrund: Die Kommunikation und Interaktion mit Menschen am Lebensende liegt im gesellschaftlichen Spannungsfeld zwischen Tabu und Wiederbelebung des Todes und stellt hohe Anforderungen an die Kompetenz der Fachpersonen. Spezialistinnen und Spezia...
Clinical Studies - Feb 1, 2013 - Dec 31, 2017
Automatically Closed
Project leader: Domeisen Benedetti Franzisca
Prevention of hepatitis C virus (HCV) and HIV-1 co-infections through induction of potent T cell responses using prime-boost viral vector vaccine regimens (PEACHI)
Feb 1, 2013The goal of the PEACHI project funded by the European Commission (FP7 framework) is to develop simple, affordable and effective vaccine strategies that can be given alone or in combination to prevent hepatitis C virus (HCV), human immunodeficiency vi...
Clinical Studies - Feb 1, 2013 - Sep 27, 2022
Automatically Closed
Project leader: Dorrell Lucy, Barnes Ellie, Hoffmann Matthias, Bergin Colm, Folgori Antonella
Members: Schmid Patrick, Vernazza Pietro
Genome-wide Gene/Exon expression analysis of late stage NSCLC treated by Erlotinib /Bevacizumab: role of tumor-stroma interactions
Feb 1, 2013Genome-wide Gene/Exon expression analysis of late stage NSCLC treated by Erlotinib /Bevacizumab: role of tumor-stroma interactions
Fundamental Research - Feb 1, 2013 - Jun 1, 2015
Completed
Project leader: Baty Florent
Members: Brutsche Martin, Oliver Dürr, Franzini Anca
“The use of QUTENZA in standard clinical practice: a phase IV, multicentre, European non-interventional study” (ASCEND)
Jan 30, 2013“The use of QUTENZA in standard clinical practice: a phase IV, multicentre, European non-interventional study” (ASCEND) EKSG 12/149/1B „The use of QUTENZA in standard clinical practice: a multicentre, European NIS“. Das Ziel dieser Studie ist es, di...
Clinical Studies - Jan 30, 2013 - Jan 30, 2013
Completed
Project leader: Hoederath Petra
Members: Ott Alexander
Cetuximab monotherapy and cetuximab plus capecitabine as first-line treatment in elderly patients with KRAS- and BRAF wild-type metastatic colorectal cancer. A multicenter phase II trial, Leit-EK Zürich
Jan 10, 2013Etwa 50% der Patienten mit kolorektalem Karzinom sind bei Erstdiagnose bereits 70 Jahre oder älter. Bislang wurden allerdings nur sehr wenige Studien gezielt für ältere Patienten durchgeführt, die häufig neben der Tumorerkrankung weitere alterstypisc...
Clinical Studies - Jan 10, 2013 - Sep 27, 2022
Aborted
Project leader: Horber Daniel
Members: Gueller Ulrich, Diem Stefan