Projects
Search from 1147 projects:
1147 Project(s)
SpA: AIN 457F2320
Aug 5, 2015A randomized, double-blind, placebo-controlled, phase III multicenter study of subcutaneous secukinumab (150 mg) with and without a subcutaneous loading regimen to assess efficacy, safety, and tolerability up to 2 years in patients with active ankylo...
Clinical Studies - Aug 5, 2015 - Aug 16, 2018
Completed
Project leader: Müller Rüdiger
Members: Forrer Silvia, Bartz-Batliner Mira, Hutz Carina Liane, Schmidig Kathrin
Erforschung von Frailty und milden kognitiven Beeinträchtigungen in erwachsenen Nierentransplantationspatienten zur Verbesserung der Risikovorhersage in Bezug auf klinische, psychosoziale, und gesundheitsökonomische Ergebnisse
Aug 4, 2015Es wird untersucht, ob erwachsene Nierentransplantationspatienten Symptome von körperlicher Gebrechlichkeit oder milde Gedächtnisveränderungen aufweisen. Gebrechliche Personen haben eine reduzierter Leistungsfähigkeit und eine vermehrte Anfälligkeit...
Clinical Studies - Aug 4, 2015 - Feb 1, 2022
Automatically Closed
Project leader: Binet Françoise-Isabelle
CaCo: Does caffeine intake reduce postoperative bowel paralysis after elective laparoscopic colectomy? - A randomized placebo controlled trial
Aug 1, 2015Background Postoperative bowel paralysis is common after abdominal operations, including colectomy. As a result, hospitalization may be prolonged leading to increased cost. A recent randomized controlled trial from the University of Heidelberg showed...
Clinical Studies - Aug 1, 2015 - Jul 31, 2022
Automatically Closed
Project leader: Steffen Thomas
Members: Mueller Sascha, Beutner Ulrich, Luethi Cornelia, Warschkow Rene, Tarantino Ignazio, Brunner Walter, Marti Lukas
Next Generation Sequencing-enabled Diagnostics as a Cornerstone for Personalized (Nano-)Medicine
Jul 9, 2015
Fundamental Research - Jul 9, 2015 - Jul 9, 2016
Completed
Project leader: Jochum Wolfram
An open-label, multicohort, phase II study of MPDL3280A in advanced solid tumors
Jul 8, 2015MO29518 ist eine offene, multizentrische, multinationale Phase-II-Studie mit 10 Kohorten, welche MPDL3280A (Anti-PD-L1 Antikörper) bei Patienten mit fortgeschrittenen soliden Tumoren untersucht (Gebärmutterhalskrebs, Nasen-Rachenkrebs, spezielle Art...
Clinical Studies - Jul 8, 2015 - Jul 31, 2019
Automatically Closed
Project leader: Gillessen Sommer Silke
Members: Schmid Sabine, Fischer Stefanie, Rothermundt Christian, Templeton Arnoud, Omlin Aurelius, Desax Marie-Claire, Früh Martin, Weisshaupt Christian
Cardiopulmonary- and hemodynamic responses during positive and negative airway pressure in patients with chronic obstructive pulmonary disease (COPD)
Jul 1, 2015The overall aim of the present study is to investigate if positive and negative airway pressure influences cardiopulmonary- and hemodynamic responses by adding resistive loads or/and conducting NPPV throughout the entire breathing cycle in patients w...
Fundamental Research - Jul 1, 2015 - Mar 1, 2016
Automatically Closed
Project leader: van Gestel Arno Jr
Members: Baty Florent, Brutsche Martin
GA289103/Gardenia
Jun 28, 2015GA29103: PHASE III, RANDOMIZED, MULTICENTER DOUBLE-BLIND, DOUBLE-DUMMY STUDY TO EVALUATE THE EFFICACY AND SAFETY OF ETROLIZUMAB COMPARED WITH INFLIXIMAB IN PATIENTS WITH MODERATE TO SEVERE ACTIVE ULCERATIVE COLITIS WHO ARE NAIVE TO TNF INHIBITORS
Clinical Studies - Jun 28, 2015 - Jun 28, 2020
Automatically Closed
Project leader: Borovicka Jan
Members: Dora Barbara, Frei Remus, Knellwolf Christina, Sulz Michael, Semadeni Gian-Marco
Effect of counselling during pulmonary rehabilitation on self-determined motivation towards physical activity in patients with Chronic Obstructive Pulmonary Disease
Jun 15, 2015The overall aim of the present study is to investigate if a PA counselling program during PR increases PA level in daily life in patients with COPD.
Fundamental Research - Jun 15, 2015 - Jan 31, 2017
Automatically Closed
Project leader: van Gestel Arno Jr
Members: Rausch Osthoff Anne-Kathrin, Baty Florent, Hess Thomas
Characterizing sleep apnea by using a wearable electro EMPA cardiogram device
Jun 1, 2015The primary aim of the present study is to analyze the validity and feasibility of a wearable ECG Acquisition System (EMPA) by comparing standard measures of heart rate variability (Low-frequency power, LF) with those of polysomnography.
Fundamental Research - Jun 1, 2015 - Dec 1, 2016
Automatically Closed
Project leader: Brutsche Martin
Members: Baty Florent, van Gestel Arnoldus, Rossi Rene, Annaheim Simon, Weder Markus, Schoch Otto
A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of AMG 334 in Migraine Prevention (ARISE-Study)
Jun 1, 2015To evaluate the effect of AMG 334 compared to placebo on the change from baseline in monthly migraine days, in subjects with episodic migraine
Clinical Studies - Jun 1, 2015 - Dec 31, 2017
Automatically Closed
Project leader: Flügel Dominique
Members: Zieglgänsberger Dominik, Müller Anna
Outcome after operative treatment of intra-articular calcaneal fractures
May 15, 2015Among all the bones in the foot the calcaneus is the most commonly fractured one, counting for 1 – 2% of all fractures. Calcaneus fractures are very complex injuries with regard to the damage of the bone, the cartilage of the subtalar joint and the s...
Clinical Studies - May 15, 2015 - Dec 31, 2016
Automatically Closed
Project leader: Schirm Andreas
aSCore: LONG-TERM EXPERIENCE WITH ABATACEPT SC IN ROUTINE CLINICAL
May 6, 2015STUDY DESIGN Overview of Study Design This is a non-interventional, multicenter, study consisting of 2 prospective cohorts of patients diagnosed with moderate to severe active RA and initiated/treated with abatacept SC. In some countries, patients ca...
Clinical Studies - May 6, 2015 - Oct 6, 2017
Completed
Project leader: Müller Rüdiger
Members: Forrer Silvia, Schmidig Kathrin, Bartz-Batliner Mira, Hutz Carina Liane
A phase III, open-label, multicenter, randomized study to investigate the efficacy and safety of MPDL3280A (ANTI−PD-L1 ANTIBODY) compared with chemotherapy in patients with locally advanced or metastatic urothelial bladder cancer after failure with platinum-containing chem-otherapy. GO29294
Apr 2, 2015Dies ist eine globale, multizentrische, offene, zweiarmige, randomisierte, kontrollierte Phase-III Studie zur Beurteilung der Wirksamkeit und Sicherheit von MPDL3280A im Ver-gleich mit Chemotherapie bei Patienten mit lokal fortge-schrittenem oder met...
Clinical Studies - Apr 2, 2015 - Dec 1, 2016
Automatically Closed
Project leader: Gillessen Sommer Silke
Members: Templeton Arnoud, Rothermundt Christian, Omlin Aurelius, Desax Marie-Claire
Evaluation and verification of serological activity markers in systemic lupus erythematosus
Apr 1, 2015Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease. So far, there is little evidence for the existence of specific biologic markers reliably indicating clinical activity and a rather wide panel of unspecific markers indica...
Fundamental Research - Apr 1, 2015 - Mar 31, 2018
Automatically Closed
Project leader: von Kempis Johannes
Members: Schmiedeberg Kristin
Modeling human neurodegenerative disease by iPS cell-derived neurons
Apr 1, 2015Gewinnung von kutanen Stammzellen mittels Stanzbiopsie bei Patienten mit genetischer amyotropher Lateralsklerose sowie asymptomatischen Angehörigen mit und ohne Mutationsnachweis.
Fundamental Research - Apr 1, 2015 - Dec 31, 2017
Completed
Project leader: Weber Markus
Improving the activity of proteasome inhibitors for potential treatment of
Mar 31, 2015Traditional chemotherapy fails to cure renal cell carcinoma (RCC), hence novel approaches and mechanisms need to be exploited.Proteotoxic stress-induced apoptosis can be induced in cancer cells by interfering with the homeostasis of protein biosynthe...
Fundamental Research - Mar 31, 2015 - Dec 7, 2018
Automatically Closed
Project leader: Abt Dominik
Members: Engeler Daniel, Driessen Christoph, Kraus Marianne, Bader Jürgen
OPTIMIS - Beobachtung der Behandlung mit oder ohne Nexavar von Patienten mit HCC nach erfolgter TACE und des Einschlusses des zeitlichen Beginns der nexavartherapie
Mar 30, 2015
Clinical Studies - Mar 30, 2015 - Sep 30, 2017
Completed
Members: Alfter Christine, Bernsmeier Christine, Künzler-Heule Patrizia, Semela David
Nutzen der wiederholten transkraniellen Doppler-Mikroemboliedetektion beim akuten ischämischen Schlaganfall
Mar 30, 2015Der Schlaganfall ist die zweithäufigste Todesursache und die häufigste Ursache einer erworbenenBehinderung im Erwachsenenalter. Für die meisten Patienten ist eine effiziente Sekundärprophylaxe die wirksamste Prävention um die Häufigkeit von Schlaganf...
Clinical Studies - Mar 30, 2015 - Mar 31, 2016
Completed
Project leader: Kägi Georg
Members: Vehoff Jochen
Abbvie M14-423 An Open Label, Multicenter Study to Evaluate Long-Term Outcomes With ABT-450/Ritonavir/ABT-267 and ABT-333 With or Without Ribavirin in Adults With Genotyp 1 Chronic Hepatitis C Infection
Mar 26, 2015
Clinical Studies - Mar 26, 2015 - Mar 31, 2020
Automatically Closed
Project leader: Semela David
Members: Bernsmeier Christine, Künzler-Heule Patrizia, Stillhard Roman
SENIOR
Mar 26, 2015Kurzzeitige duale Thrombozytenaggregationshemmer-Therapie mit Everolimus freisetzenden Stents Synergy® II bei Patienten über 75 Jahren, die eine perkutane Koronarrevaskularisierung erhalten. Ziele: Nachweis der Wirksamkeit und Sicherheit der Everol...
Clinical Studies - Mar 26, 2015 - Nov 30, 2018
Completed
Project leader: Weilenmann Daniel
Members: Schneider Irene