Projects
Search from 1147 projects:
1147 Project(s)
Single arm open label phase II pilot study of carboplatin in patients with metastatic castration-resistant prostate cancer (CRPC) and PTEN-loss and/or DNA repair defects. PRO-PLAT
Feb 17, 2016Clinical studies in unselected prostate cancer patients strongly support the hypothesis that platinums have anti-tumour activity in some patients with CRPC. For patients progressing after docetaxel based chemotherapy and a novel androgen receptor tar...
Clinical Studies - Feb 17, 2016 - Jan 1, 2019
Automatically Closed
Project leader: Omlin Aurelius
Escitalopram: Effects of serotonergic neuromodulation on behavioural recovery and motor network plasticity after cortical ischemic stroke: a longitudinal, placebo-controlled study
Feb 1, 2016This randomized, double blind, placebo-controlled longitudinal study encompassing behavioural, neurophysiological and neuroimaging endpoints is designed to test our hypothesis, based on results from our previous pilot study, that serotonergic neuromo...
Clinical Studies - Feb 1, 2016 - Feb 1, 2018
Completed
Project leader: Kägi Georg
Members: Müller Anna
A multicenter, randomized, double-blind, parallel-group,placebo-controlled variable treatment duration studyevaluating the efficacy and safety of Siponimod (BAF312)in patients with secondary progressive multiple sclerosisfollowed by extended treatment with open-label BAF312
Feb 1, 2016Extensionsstudie, Evaluation Sicherheit und Wirksamkeit von Siponimod bei sekundär progredienter MS.
Clinical Studies - Feb 1, 2016 - Feb 1, 2020
Automatically Closed
RESPECT ESUS: Randomized, double-blind, Evaluation in secondary Stroke Prevention comparing the EfficaCy and safety of the oral Thrombin inhibitor dabigatran etexilate (110 mg or 150 mg, oral b.i.d.) versus acetylsalicylic acid (100 mg oral q.d.) in patients with Embolic Stroke of undetermined Source
Jan 22, 2016There is uncertainty over the optimal stroke prevention treatment for patients with ESUS. The current treatment recommendations of ASA alone, sometimes given with clopidogrel or ticlopidine (P08-06684, P08-08481) are based on limited data. There is s...
Clinical Studies - Jan 22, 2016 - Jan 1, 2018
Automatically Closed
Project leader: Kägi Georg
Members: Vehoff Jochen, Müller Anna, Mbialeu Suzie
Adjuvant aspirin treatment in PIK3CA mutated colon cancer patients. A randomized, double-blinded, placebo-controlled, phase III trial
Jan 20, 2016Dickdarmkrebs gehört zu den häufigsten bösartigen Tumoren weltweit. Die meisten Patienten mit Dickdarmkrebs unterziehen sich einer Operation. Trotz kompletter Entfernung des Dickdarmkrebs und eventuell zusätzlicher Chemotherapie ist jedoch das Risiko...
Clinical Studies - Jan 20, 2016 - Feb 1, 2028
Ongoing
Project leader: Gueller Ulrich
Abbvie M13-590 “A Randomized, Open-Label, Multicenter Study to Evaluate the Efficacy and Safety of ABT-493/ABT-530 in Adults with Chronic Hepatitis C Virus Genotype 1 Infection
Jan 2, 2016
Clinical Studies - Jan 2, 2016 - Mar 2, 2017
Completed
Project leader: Semela David
Members: Alfter Christine
Abbvie M13-594 A Randomized, Open-Label, Active-Controlled, Multicenter Study to Compare Efficacy and Safety of ABT-493/ABT-530 to Sofosbuvir Co-Administered with Ribavirin in Adults with Chronic Hepatitis C Virus Genotype 3 Infection
Jan 2, 2016
Clinical Studies - Jan 2, 2016 - Mar 2, 2017
Completed
Project leader: Semela David
Members: Alfter Christine
Bone mineral density of the proximal humerus in patients with glenohumeral osteoarthritis : intraoperative assessment and impact on treatment alternatives
Jan 1, 2016The bone quality (bone mineral density - BMD) of the proximal humerus might be crucial for clinical outcome of some new and evolving shoulder arthroplasty systems like the stemless humeral components, which relies on uncemented pressfit fixation in t...
Fundamental Research - Jan 1, 2016 - Oct 1, 2017
Automatically Closed
Project leader: Jost Bernhard
Members: Zdravkovic Vilijam, Puskas Gabor, Kaufman Rolf
COBRA REDUCE - Cobra PzF Stenting to Reduce the Duration of Triple Therapy in Patients Treated with Oral Anticoagulation Undergoing Percutaneous Coronary Intervention
Jan 1, 2016Hypothesis: In patients undergoing coronary intervention who are receiving oral anticoagulation, Cobra PzF stents with 14 days of DAPT after stenting provide superior outcomes versus Xience/Promus or Resolute drug-eluting stents with 6 months of DAPT...
Clinical Studies - Jan 1, 2016 - Mar 31, 2019
Completed
Project leader: Weilenmann Daniel
Members: Schneider Irene
Spire 1022
Jan 1, 2016Diese Studie dient dem Beleg der Überlegenheit von PF-04950615, einem PCSK9 Inhibitor, gegenüber einem Placebo bzgl. Risikoreduktion von kardiovaskulären Ereignissen bei Patienten mit sehr hohem kardiovaskulären Risiko und persistierend erhöhtem LDL-...
Clinical Studies - Jan 1, 2016 - Aug 31, 2017
Aborted
Project leader: Bilz Stefan
Members: Jenni Vera
Spire 1038
Jan 1, 2016Diese Studie dient der Evaluation der Wirksamkeit, Sicherheit und Tolerabilität von PF 04950615, einem PCSK9 Inhibitor, bzgl. Reduktion von schweren kardiovaskulären Ereignissen bei Patienten mit hohem und sehr hohen Risiko (LDL-C ≥2.6 mmol/L).
Clinical Studies - Jan 1, 2016 - Aug 31, 2018
Aborted
Project leader: Bilz Stefan
Members: Jenni Vera
TOUJEO I
Jan 1, 2016Diese Studie dient der Erforschung des klinischen Vorteils eines Therapieausbaus mit Insulin Glargin U300 (Toujeo®), einem neuen Basalinsulin, bei Patienten, deren Diabetes mellitus Typ 2 unter Therapie mit oralen Antidiabetika ungenügend kontrollier...
Clinical Studies - Jan 1, 2016 - Jan 1, 2020
Completed
Project leader: Aczel Stefan
Members: Bilz Stefan
CODDI
Jan 1, 2016Diese Studie testet den Stellenwert von Copeptin, einem neuen Biomarker, bei der Diagnose eines Diabetes insipidus im Vergleich zu den herkömmlichen Parametern.
Clinical Studies - Jan 1, 2016 - Oct 31, 2017
Completed
Project leader: Brändle Michael, Christ-Crain Mirjam, Fenske Wiebke
Members: Bilz Stefan, Drescher Tilman
EFFORT
Jan 1, 2016Diese Studie untersucht, ob eine früh eingeleitete, individualisierte Ernährungstherapie zur Erreichung eines Ernährungsziels bei Patienten mit Risiko für eine Mangelernährung eine kosteneffektive Strategie zur Reduktion von Mortalität, Morbidität un...
Clinical Studies - Jan 1, 2016 - Jan 1, 2020
Completed
Project leader: Bilz Stefan, Schütz Philipp
Members: Sigrist Sarah
Vaccine and immunotherapy induced CD8+ T cell responses against auto-, neo- and foreign antigens
Jan 1, 2016The growing incidence of melanoma is an increasing threat, and effective treatment options for advanced forms of melanoma are scarce. Although recently approved targeted- and immunotherapies have shown objective beneficial effects in metastatic melan...
Fundamental Research - Jan 1, 2016 - Dec 31, 2019
Automatically Closed
Project leader: Flatz Lukas
Members: Ring Sandra, Królik Michał Wojciech, Berner Fiamma
Targeting breast cancer through manipulation of IL-7 producing tumor fibroblasts
Jan 1, 2016Breast cancer is by far the most frequent gynaecological cancer. Despite considerable advances in antitumor therapies during the last 15 years, metastatic and recurrent breast cancer is still incurable, indicating that the underlying pathogenesis of...
Fundamental Research - Jan 1, 2016 - Dec 31, 2017
Automatically Closed
Project leader: Ludewig Burkhard
Members: Bösch Maximilian
Evaluation of Controlled Attenuated Parameter (CAP) for Assessment of Liver Steatosis in an Unselected Population: a Single Center Real Life Experience
Dec 16, 2015Background & Aims: Controlled attenuated parameter (CAP) is a new parameter to assess steatosis of the liver, which is obtained together with elastography. Our aim was to assess the performance of CAP in an unselected population with different liver...
Clinical Studies - Dec 16, 2015 - Dec 16, 2017
Completed
Project leader: Baumeler Stephan
Members: Semela David, Bergamin Irina, Jochum Wolfram, Neuweiler Jörg
WRAP-IT
Dec 15, 2015Wirksamkeit der TYRX-Hülle hinsichtlich des Infektionsrisikos im Zusammenhang mit Herzrhythmusimplantaten innerhalb 12 Monaten nach dem Eingriff
Clinical Studies - Dec 15, 2015 - Aug 31, 2018
Completed
Project leader: Ammann Peter
Members: Vetsch Susanne
LONGEVITY Study
Dec 14, 2015The objective of this non-mandated, prospective, multicenter, global post-market study is to assess the battery and device longevity of Boston Scientific’s (BSC) market-released Implantable Cardioverter Defibrillators (ICD) and CRT-D devices. The stu...
Clinical Studies - Dec 14, 2015 - Nov 30, 2021
Completed
Project leader: Ammann Peter
Members: Schneider Irene
Liver metastasis in colorectal carcinoma: Accuracy of Contrast-enhanced ultrasound (CEUS) in comparison with computertomography on new diagnosed CRC with impact on therapy strategy?
Dec 1, 2015Background: Up to 20% of liver metastasis could be missed by CT according to the oncological staging in colorectal carcinoma Primary endpoint: Detection of colorectal liver metastasis (CRLM) – comparison of CEUS with CT (hypothesis CEUS with better s...
Clinical Studies - Dec 1, 2015 - Nov 1, 2018
Automatically Closed
Project leader: Sawatzki Mikael
Members: Alfter Christine, Semela David, Gueller Ulrich, Horber Daniel, Bergamin Irina