CaCo: Does caffeine intake reduce postoperative bowel paralysis after elective laparoscopic colectomy? - A randomized placebo controlled trial - Project

Project

CaCo: Does caffeine intake reduce postoperative bowel paralysis after elective laparoscopic colectomy? - A randomized placebo controlled trial

Automatically Closed · 2015 until 2022

Steffen Thomas, Mueller Sascha, Beutner Ulrich, Luethi Cornelia, Warschkow Rene, Tarantino Ignazio, Brunner Walter, Marti Lukas

Type

Clinical Studies

Range

Monocentric project at KSSG

Units

Clinic for General, Visceral, Endocrine and Transplant Surgery

Status

Automatically Closed

Start Date

2015

End Date

2022

Financing

Others

Study Design

Interventional Allocation: randomized Intervention model: parallel assignment Masking: double blind Primary purpose: prevention

Keywords

caffeine, bowel paralysis, colectomy, ileus, surgery

Brief description/objective

Background
Postoperative bowel paralysis is common after abdominal operations, including colectomy. As a result, hospitalization may be prolonged leading to increased cost. A recent randomized controlled trial from the University of Heidelberg showed that consumption of regular black coffee after colectomy is safe and associated with a significantly faster resumption of intestinal motility. The mechanism how coffee stimulates intestinal motility is unknown but caffeine seems to be the most likely stimulating agent.

Aim
Investigation of the effects of caffeine on the return of bowel function and appetite, length of hospital stay, and complications after elective laparoscopic colectomy.

Intervention
Arm 1: postoperative intake of 3x placebo daily
Arm 2: postoperative intake of 3x 100 mg caffeine daily
Arm 3: postoperative intake of 3x 200 mg caffeine daily