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With the establishment of polychemotherapy and the con-tinuous advancements in radiotherapy, Hodgkin lymphoma has meanwhile become a malignant oncological disease in adults with one of the best prognoses of all. The outcome improvements in Hodgkin lymphoma patients have been achieved by strict quality standards across all medical dis-ciplines involved in diagnostics and treatment including pathology, radiology, nuclear medicine, radiotherapy and oncology. In the first-line treatment of advanced stage Hodgkin lymphoma there is still a strong need for further optimization regarding treatment-related acute and late toxicities. Therefore, the German Hodgkin Study Group (GHSG) strives to develop a new, modified treatment reg-imen in order to minimize side-effects while maintaining the response to treatment at the same high level.