PD Dr. med. Georg Kägi
chief of service
Neurologie · Dept. III
The motor side of neglect
Apr 1, 2023Motor neglect (MN), which denotes an underutilization of the contralesional limbs not explained by sensorimotor deficits, and premotor neglect (PMN), a directional disorder of movements towards or in the contralateral hemispace, are functionally disa...
Clinical Studies - Apr 1, 2023 - Dec 31, 2025
Ongoing
Project leader: Kägi Georg
Members: Schneider Thomas
SILENT 2
Dec 4, 2020Incidence of Silent Atrial Fibrillation in Patients With Clinically Silent Brain Ischemic Lesions Arterial Fibrillation (AF) is well-recognized as a cause for cryptogenic Acute Ischemic Stroke (AIS) and is associated with Silent Brain Infarction...
Clinical Studies - Dec 4, 2020 - Dec 4, 2024
Ongoing
Project leader: Ammann Peter, Kägi Georg
Members: Brenner Roman, Vetsch Susanne, Schneider Irene
The role of the sensory trick in gating multimodal afferents in adult-onset idiopathic cervical dystonia
Aug 15, 2018The ‘sensory trick’ (ST) refers to a particular manoeuver e.g. slightly touching the face, which is capable of significantly ameliorating the abnormal head posture in patients with cervical dystonia (CD) (synonym: torticollis). The benefit is sometim...
Fundamental Research - Aug 15, 2018 - Jul 31, 2020
Automatically Closed
Project leader: Brugger Florian
Members: Kägi Georg
Early versus Late initiation of direct oral Anticoagulants in post-ischaemic stroke patients with atrial fibrillatioN (ELAN): an international, multicentre, randomised-controlled, two-arm, assessor-blinded trial
Aug 31, 2017Inhalt und Ziele des Forschungsprojektes Ein Hirnschlag kann durch ein Vorhofflimmern des Herzens (das heisst unregelmässiger Herzrhythmus) ausgelöst werden. Patienten mit einem solchen Hirnschlag sind einem erhöhten Risiko ausgesetzt weitere Hirnsch...
Clinical Studies - Aug 31, 2017 - Jul 31, 2021
Automatically Closed
Project leader: Vehoff Jochen, Kägi Georg
TICH-NOAC (Treatment of intracerebral hemorrhage in patients on non-vitamin K oral anticoagulants with tranexamic acid
Aug 22, 2017Neue, direkte, nicht Vitamin-K antagonisierende orale Antikoagulantien (NOAC oder DOAC) sind wirksame Medikamente zur Prophylaxe und Behandlung einer Vielzahl von thrombembolischen Erkrankungen wie zum Beispiel der Hirnschlagprophylaxe bei Patienten...
Clinical Studies - Aug 22, 2017 - Dec 31, 2019
Automatically Closed
Project leader: Kägi Georg
Members: Vehoff Jochen
eSATIS: Early Sleep Apnea Treatment in Stroke: A Randomized, Rater-Blinded, Clinical Trial of Adaptive Servo-Ventilation
Jun 20, 2016The prevalence of Sleep Disordered Breathing (SDB) after acute stroke is high (over 50% of affected patients in more than 20 studies). SDB after stroke has been found to be associated with a faster progression of stroke severity, with higher blood pr...
Clinical Studies - Jun 20, 2016 - Jun 20, 2018
Automatically Closed
Project leader: Flügel Dominique
Members: Kägi Georg
A Prospective, Multicenter, Observational, Single-arm European Registry on the ACE Reperfusion Catheters and the Penumbra System in the Treatment of Acute Ischemic Stroke
Jun 2, 2016Study Objective: To observe the safety and effectiveness of the ACE Reperfusion Catheters and the Penumbra System in patients with acute ischemic stroke from large vessel occlusion, treated with the ADAPT technique in site routine practice. Study De...
Clinical Studies - Jun 2, 2016 - May 31, 2017
Completed
Members: Vehoff Jochen, Kägi Georg, Müller Anna
TICH-2: Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage
Mar 1, 2016Despite development of effective treatments for ischaemic stroke (thrombolysis, aspirin, hemicraniectomy) there is no proven effective treatment for spontaneous intracerebral haemorrhage (SICH). Trials conducted with treatments such as intesive blood...
Clinical Studies - Mar 1, 2016 - Mar 1, 2018
Completed
Project leader: Kägi Georg
Members: Vehoff Jochen
BIOSIGNAL: Biomarker signature of stroke aetiology study
Feb 20, 2016In 25-39% der Fälle kann die Schlaganfall-Ursache trotz sorgfältiger Abklärungen nicht gefunden werden1. Diese Patienten können unter Umständen nicht einer adäquaten Sekundärprävention zugeführt werden. Dies ist insbesondere der Fall bei Patienten mi...
Clinical Studies - Feb 20, 2016 - Feb 20, 2018
Automatically Closed
Project leader: Kägi Georg
Escitalopram: Effects of serotonergic neuromodulation on behavioural recovery and motor network plasticity after cortical ischemic stroke: a longitudinal, placebo-controlled study
Feb 1, 2016This randomized, double blind, placebo-controlled longitudinal study encompassing behavioural, neurophysiological and neuroimaging endpoints is designed to test our hypothesis, based on results from our previous pilot study, that serotonergic neuromo...
Clinical Studies - Feb 1, 2016 - Feb 1, 2018
Completed
Project leader: Kägi Georg
RESPECT ESUS: Randomized, double-blind, Evaluation in secondary Stroke Prevention comparing the EfficaCy and safety of the oral Thrombin inhibitor dabigatran etexilate (110 mg or 150 mg, oral b.i.d.) versus acetylsalicylic acid (100 mg oral q.d.) in patients with Embolic Stroke of undetermined Source
Jan 22, 2016There is uncertainty over the optimal stroke prevention treatment for patients with ESUS. The current treatment recommendations of ASA alone, sometimes given with clopidogrel or ticlopidine (P08-06684, P08-08481) are based on limited data. There is s...
Clinical Studies - Jan 22, 2016 - Jan 1, 2018
Automatically Closed
Project leader: Kägi Georg
Members: Vehoff Jochen, Mbialeu Suzie
Verticality perception in patients with acute lateralized lesions along the central graviceptive pathways - acute assessment on the ward an the stroke center
Oct 21, 2015Multizentrisches Forschungsprojekt zur Untersuchung der Wahrnehmung der Schwerkraft bei Patienten mit einem akuten Schlaganfall im Vergleich zu gesunden Kontrollpersonen.
Clinical Studies - Oct 21, 2015 - Mar 31, 2016
Automatically Closed
Members: Lübbert Annette, Kägi Georg
TREAT CAD: Biomarkers and antithrombotic treatment in cervical artery dissection
Oct 15, 2015Zur Therapie von Dissektionen werden gerinnungshemmende Medikamente eingesetzt (antithrombotische Therapie), um der Entstehung von Blutgerinnseln und deren Folgen wie Gefässverschlüsse und Durchblutungsstörungen des Gehirns entgegenzuwirken. Jedoch k...
Clinical Studies - Oct 15, 2015 - Dec 20, 2018
Completed
Project leader: Kägi Georg
Members: Vehoff Jochen
Nutzen der wiederholten transkraniellen Doppler-Mikroemboliedetektion beim akuten ischämischen Schlaganfall
Mar 30, 2015Der Schlaganfall ist die zweithäufigste Todesursache und die häufigste Ursache einer erworbenenBehinderung im Erwachsenenalter. Für die meisten Patienten ist eine effiziente Sekundärprophylaxe die wirksamste Prävention um die Häufigkeit von Schlaganf...
Clinical Studies - Mar 30, 2015 - Mar 31, 2016
Completed
Project leader: Kägi Georg
Members: Vehoff Jochen
Predictive Swallowing Score (PRESS)
Mar 1, 2015We have developed the Predictive Swallowing Score (PRESS) - an easily applicable prognostic risk score of impaired oral intake after stroke. The 10 point score is calculated after the initial swallowing evaluation in the first days after stroke and s...
Clinical Studies - Mar 1, 2015 - Dec 31, 2016
Automatically Closed
Project leader: Kägi Georg
Members: Galovic Marian, Leisi Natascha, Müller Marlise, Stöckli Sandro, Arnold Marcel, Lyrer Philippe, Kahles Timo
Structural brain changes and dysphagia in Parkinson's disease
Jan 1, 2014
Clinical Studies - Jan 1, 2014 - Dec 31, 2015
Automatically Closed
Project leader: Kägi Georg
Members: Galovic Marian, Brugger Florian, Stöckli Sandro, Müller Marlise
Randomisierte, doppelblinde, multinationale Studie zur Prävention schwerwiegender vaskulärer Ereignisse mit Ticagrelor im Vergleich zu Aspirin® (ASS) bei Patienten mit akutem ischämischen Schlaganfall oder einer transitorisch-ischämischen Attacke (TIA)
Nov 21, 2013Hintergrund der Studie: Nach einem ischämischen Hirninfarkt oder einer transitorisch-ischämischen Attacke (TIA) sind die Patienten einem erhöhten Risiko eines nachfolgenden ischämischen Hirninfarkts, Myokardinfarkts (MI) oder Tod ausgesetzt. Die Beh...
Clinical Studies - Nov 21, 2013 - Jan 25, 2016
Completed
Project leader: Kägi Georg
Members: Vehoff Jochen
Clinical and MRI based predictors of prolonged dysphagia in ischemic stroke
Jan 1, 2013Background With an incidence of approximately 55% swallowing disorders after ischemic stroke are a regular issue and can lead to complications like pneumonia, malnutrition and dehydration. The presence of dysphagia in stroke patients may be associat...
Clinical Studies - Jan 1, 2013 - Jul 31, 2014
Completed
Project leader: Kägi Georg
Members: Galovic Marian, Weder Bruno, Stöckli Sandro, Leisi Natascha, Müller Marlise, Weber Johannes
Pilotstudie: Die Bedeutung der supplementär-motorischen Area bei der Pathophysiologie des Freezing of Gait beim Morbus Parkinson
Dec 1, 2011Das Freezing of Gait (FOG) stellt ein schwerwiegendes und invalidisierendes Symptom beim fortgeschrittenen Morbus Parkinson dar, da es aufgrund seines paroxysmalen Auftretens den Patienten in seiner Mobilität einschränkt. FOG führt ausserdem vermehrt...
Clinical Studies - Dec 1, 2011 - Jun 30, 2013
Completed
Project leader: Kägi Georg, Brugger Florian
Members: Bohlhalter Stephan, Wegener Regina, Hägele-Link Stefan, Abela Eugenio
multicenter, double-blind, placebo-controlled, parallel-group, phase IV study to assess the effect of Rotigotine on non-motor symptoms in patients with idiopathic parkinson's disease
Sep 1, 2011Multizentrische, doppelblinde, placebokontrollierte Parallelgruppenstudie der Phase IV zur Bestimmung der Wirkung von Rotigotin auf die nichtmotorischen Symptome bei Patienten mit idiopathischem Parkinson-Syndrom Studie SP0976
Clinical Studies - Sep 1, 2011 - Dec 31, 2012
Automatically Closed
Project leader: Tettenborn Barbara
Members: Kägi Georg, Brugger Florian, Hägele-Link Stefan